tion of patients with GERD symptoms, including typical symptoms in patients off PPIs, chronic cough and symptoms refractory to PPIs [13–15] . However, few studies have formerly assessed the benefit of impedance-pH monitoring in patients with laryngeal symptoms. Chronic cough related to GERD has been generally attributed to acid reflux. However, acid suppression therapy is not as good as for hea...

INTRODUCTION The conventional 24-hour pH monitoring is the gold standard for the diagnosis of gastro-esophageal reflux (GER), a possible cause of Apparent Life Threatening Episodes (ALTE). However, multichannel intraluminal impedance (MII) may provide advantages. OBJECTIVES Comparison of the results of MII and pH monitoring in patients undergoing MII-pH monitoring in the 3-year study period b...

OBJECTIVES A novel catheter that can measure mucosal admittance (MA), the inverse of impedance, was developed recently. In this pilot study, we aimed to clarify the usefulness of measuring MA for diagnosing gastroesophageal reflux disease (GERD). METHODS We conducted two prospective studies. In the first study, esophageal MA was evaluated in 120 participants (24 with erosive esophagitis, 82 w...

BACKGROUND Data on acid and non-acid reflux patterns and esophageal function in Japanese patients with non-erosive reflux disease (NERD) are limited. The aim of this study was to use combined multichannel intraluminal impedance pH monitoring (MII-pH) and high-resolution manometry (HRM) to investigate the characteristics of Japanese patients who were treated with a "double-dose" (20 mg) of rabep...

TO THE EDITOR: I read with great interest the paper entitled “Yield of combined impedance-pH monitoring for refractory reflux symptoms in clinical practice” by Karamanolis et al, which was published in April 2011 issue of Journal of Neurogastroenterology and Motility. Esophageal impedance pH monitoring allows detection of reflux of any composition (liquid or gas) and pH (acid, weakly acid or no...

TO THE EDITOR: We read with interest the study by Khan et al, who investigated patients with non-erosive reflux disease (NERD) refractory to anti-secretory therapy by means of impedance-pH monitoring on-therapy and concluded that nearly 60% of these patients had primarily a non-acid reflux disease. Moreover, they found that approximately half of NERD patients with normal multichannel intralumin...

OBJECTIVE To determine interobserver and intraobserver variability in pH-impedance interpretation between experts and accuracy of automated analysis (AA). STUDY DESIGN Ten pediatric 24-hour pH-impedance tracings were analyzed by 10 observers from 7 world groups and with AA. Detection of gastroesophageal reflux (GER) episodes was compared between observers and AA. Intraobserver agreement was a...

A relevant percentage of non-erosive reflux disease (NERD) is refractory to proton pump inhibitors (PPIs) treatment. Multichannel intraluminal impedance pH (MII-pH) monitoring should give useful pathophysiological information about refractoriness. Therefore, our aim was to assess whether this technique could be useful to guide a 'tailored' therapy in refractory NERD. We retrospectively recruite...