3-Cyanothiophenes could be obtained via a three-component reaction of chalcones with benzoylacetonitriles and sulfur.

We investigated the microtubule-destabilizing, vascular-targeting, anti-tumor and anti-metastatic activities of a new series of chalcones, whose prototype compound is (E)-3-(3''-amino-4''-methoxyphenyl)-1-(5'-methoxy-3',4'-methylendioxyphenyl)-2-methylprop-2-en-1-one (TUB091). X-ray crystallography showed that these chalcones bind to the colchicine site of tubulin and therefore prevent the curv...

UNLABELLED Two efficient reactions were successfully carried out using Animal Bone Meal (ABM) and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen-Schmidt condensation and then in an aza-...

Some new [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones and 3-substituted phenyl-5-substituted phenyl-4,5-dihydro-pyrazole-1-carbothioamides have been synthesized employing microwave techniques and evaluated for antimicrobial activity. Substituted acetophenones (1) were reacted with appropriately substituted benzaldehydes (2) in the presence of ethanol to furnish subst...

Objective: Synthesis of novel pyrazolines (P2-P4 & P7-P9) from the chalcones (C2-C10) obtained by condensing different aldehydes with 2-acetyl5-bromothiophene and evaluates them for in vitro anticancer and anti-inflammatory activities. Methods: The synthesized pyrazolines and chalcones were screened for anticancer activity against human breast cancer cell lines-MCF-7 and MDAMB-468 in the range ...

Various indolyl chalcones have been synthesized in unsealed vessels in a domestic microwave oven. Considerable increase in the reaction rate has been observed with better yields.

Highly enantioselective aziridination of chalcones catalyzed by a novel backbone 1,8-bisoxazolidinylanthracene (AnBOX) and CuOTf with up to >99% ee and the opposite enantioselectivity compared with the ligands of Evans are described.

tory processes, where activation of the transcription factor nuclear factor-kappa B (NF-kB) plays a pivotal role by augmenting the expression of various genes such as cytokines, chemokines, leukocyte-adhesion molecules. NF-kB is found in the cytoplasm of most cells as an inactive complex bound to an inhibitory protein, inhibitor kappa B (IkB). It is also well known that treatment with a variety...