Ataxin-1 (ATXN1) is a coregulator protein within which expansion of the polyglutamine tract causes spinocerebellar ataxia type 1, an autosomal dominant neurodegenerative disorder. Previously, we reported that ATXN1 regulates the epithelial-mesenchymal transition of cervical cancer cells. In the present study, we demonstrate that ATXN1 is involved in cervical cancer tumorigenesis by promoting th...

OBJECTIVE To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). METHODS sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls. RESULTS Both sNRP-1 and NRP-1 proteins were correlated...

OBJECTIVES We explore the clinical potential of reflectance and fluorescence confocal microscopy to image the morphologic and biochemical changes associated with precancer, in order to aid in the detection and diagnosis of cervical dysplasia. METHODS Cervical epithelial tissue samples imaged ex vivo or in vivo were obtained from M. D. Anderson Cancer Center and Lyndon B. Johnson Hospital in H...

OBJECTIVE A meta-analysis was conducted to analyze c-Met expression in cervical cancer. METHODS Articles related to our study were retrieved from PubMed, Elsevier, and China National Knowledge Infrastructure. State 12.0 was used for literature review, data extraction, and meta-analysis. The random-effects model and fixed-effects model were utilized to pool the relative ratio based on the hete...

Results from epidemiologic studies suggest that a carotenoid-rich diet may reduce risk for cervical cancer, possibly by inhibiting the progression of cervical intraepithelial neoplasia, a preneoplastic lesion of the cervical tissue. Laboratory studies suggest that the mechanism may be linked to the metabolism of carotenoids to retinoic acid or retinoic acid–like compounds, which has been hypoth...

background: chlamydia trachomatis (c. trachomatis) and mycoplasma genitalium (m. genitalium) are considered factors in cervical and ovarian cancer and are associated with flaky cell carcinoma of the cervix. the role of steady infection, leading to chronic inflammation, in the of ovarian cancer has received very little consideration, although a background of pelvic inflammatory disease (pid) is ...

The present study aimed to examine the role and underlying mechanism of miRNA-758 (miR-758) expression in cancer tissues, blood and cervical exfoliated cells from patients with cervical cancer. A total of 49 patients with cervical cancer and 26 healthy people for cervical cancer screening were included in the present study. The patients with cervical cancer were treated with resection, and the ...

BACKGROUND Our previous study reported that MEG3 is an important tumor suppressor gene that is inactivated in cervical cancer. However, the diagnostic and prognostic values of MEG3, as well as the molecular mechanism of MEG3 inactivation in cervical cancer, remain unclear. In this study, we aimed to further elucidate the role and potential inactivation mechanism of MEG3 in cervical cancer. ME...

results out of 140 samples of oca, 70 (50%) samples were malignant cancer and 70 (50%) were benign cancer as the control group. out of 70 malignant samples 25 (36.0%) were hpv-16 positive. 2.8% of the tissue samples of the control group were positive for hpv-16. conclusions these results show a feasible role of hpv-16 in the carcinogenesis of oca. according to these results, infection with hpv ...

Cervical cancer represents one of the most important malignancies among women worldwide. Current therapeutic approaches for cervical are reported not only to be inadequate metastatic cancer, but also considered as cytotoxic several patients leading serious side effects, which can have negative implications on quality life women. Therefore, there is an urgent need development innovative and effe...