BACKGROUND The aim of this investigation was to determine the effects of diclofenac on cerebral blood flow. Middle cerebral artery blood flow velocity was measured in nine patients with supratentorial tumours. METHODS Using a transcranial Doppler ultrasound, we measured the baseline mean and systolic cerebral blood flow velocity. Measurements were repeated following administration of diclofen...

We examined the cerebral circulatory effects of intra-carotid infu­ sion of histamine or its receptor agonists in anesthetized rats. Cerebral blood flow was measured by two methods: an intracarotid I:l3Xe clearance technique and tissue sampling after systemic administration of the diffusible tracer, [14C]iodoantipyrine, Brain metabolic responses were estimated by the 2deoxyglucose method and ti...

Background: Nitric oxide synthase (NOS) activity is increased during hypertension and cerebral ischemia. NOS inactivation reduces stroke-induced cerebral injuries, but little is known about its role in blood-brain barrier (BBB) disruption and cerebral edema formation during stroke in acute hypertension. Here, we investigated the role of NOS inhibition in progression of edema formation and BBB d...

In 20 patients with ischemic cerebrovascular disease, classic migraine, or angiomas, we compared paired dynamic positron emission tomographic measurements of regional cerebral blood flow using both [O]water and [F]fluoromethane as tracers. Cerebral blood flow was also determined according to the autoradiographic technique with a bolus injection of [O]water. There were reasonable overall correla...

In 20 patients with ischemic cerebrovascular disease, classic migraine, or angiomas, we compared paired dynamic positron emission tomographic measurements of regional cerebral blood flow using both [15O]water and [18F]fluoromethane as tracers. Cerebral blood flow was also determined according to the autoradiographic technique with a bolus injection of [15O]water. There were reasonable overall c...

The key to surviving hypoxia is to protect the brain from energy depletion. The epaulette shark (Hemiscyllium ocellatum) is an elasmobranch able to resist energy depletion and to survive hypoxia. Using epi-illumination microscopy in vivo to observe cerebral blood flow velocity on the brain surface, we show that cerebral blood flow in the epaulette shark is unaffected by 2 h of severe hypoxia (0...

flow during sleep and waking. J Appl Physiol 5: 620-625, 1973 15. Sakai F, Meyer JS, Karacan I, Yamaguchi F, Yamamoto M: Narcolepsy: Regional. cerebral blood flow during sleep and wakefulness. Neurology (Minneap) 29: 61-67, 1979 16. H^edt-Rassmussen K: Regional cerebral blood flow: The intraarterial injection method. Acta Neurol Scan 27: 39-41, 1967 17. Lassen NA, Ingvar DH: Radioisotopic asses...

We measured cerebral blood flow in 10 consecutive, but selected, patients with acute ischemic stroke (less than 48 hours after onset) before and after hemodilution. Cerebral blood flow was measured by xenon-133 inhalation and emission tomography, and only patients with focal hypoperfusion in clinically relevant areas were included. Hemodilution was done according to the hematocrit level: for a ...

Influence of Changes in Blood Pressure on Cerebral Oxygenation: Role of Skin Blood Flow? To the Editor: We read with interest the report from Lucas et al1 in the recent issue of Hypertension. We agree with the findings presented on cerebral blood flow with transcranial ultrasound Doppler, but we propose an alternative interpretation of the cerebral oxygenation data. As pointed out by the author...

The effects of visual stimulation on the cerebral blood flow were studied in pretrigeminal cats. The visual stimulus was a feather duster which was moved for 4-5 min in front of the cats eyes. The cerebral blood flow was measured each 15 min with [133]Xe clearance method in the left occipital lobe. The visual stimulation evoked an increase of the cerebral blood flow which was accompanied by an ...