MOTIVATION Classification of biological samples by microarrays is a topic of much interest. A number of methods have been proposed and successfully applied to this problem. It has recently been shown that classification by nearest centroids provides an accurate predictor that may outperform much more complicated methods. The 'Prediction Analysis of Microarrays' (PAM) approach is one such exampl...

Article history: Received 30 October 2015 Received in revised form 3 March 2016 Accepted 8 March 2016 Available online 17 March 2016 In many scientific areas, researchers collect multivariate time profile data on the evolution of a set of variables across time for multiple persons. For instance, clinical studies often focus on the effects of an intervention on different symptoms for multiple pe...

An imager chip has been designed, fabricated, and tested having two unique pixel types interleaved on the same array. The dual-pixel design enables optimization for two separate tasks. One type of pixel is an Active Pixel Sensor (APS), which is used to produce a low-noise image. The other type is a custom-designed pixel optimized for computing the centroid of a moving object in the scene. The A...

Abstract Quantum machine learning has seen considerable theoretical and practical developments in recent years become a promising area for finding real world applications of quantum computers. In pursuit this goal, here we combine state-of-the-art algorithms hardware to provide an experimental demonstration application with provable guarantees its performance efficiency. particular, design Near...

Aims. We use the IBIS/ISGRI telescope on board INTEGRAL to measure the position of the centroid of the 20-200 keV emission from the Crab region. Methods. We find that the astrometry of the IBIS telescope is affected by the temperature of the IBIS mask during the observation. After correcting for this effect, we show that the systematic errors on the astrometry of the telescope are of the order ...

OBJECTIVE To determine the effect of using Euclidean measurements and zip-code centroid geo-imputation versus more precise spatial analytical techniques in health care research. DATA SOURCES Commercially insured members from a southeastern managed care organization. STUDY DESIGN Distance from admitting inpatient facility to member's home and zip-code centroid (geographic placement) was comp...

Ligand burial depth is an indicator of protein flexibility, as the extent of receptor conformational change required to bind a ligand in general varies directly with its depth of burial. In a companion paper (Reyes, V.M. 2015a), we report on the Tangent Sphere (TS) and Cutting Plane (CP) methods -- complementary methods to quantify, independent of protein size, the degree of ligand burial in a ...