In this study, extraction of amoxicillin (AMOX) ions from aqueous solution by liquid-liquid extraction (LLE) was investigated. The LLE process by response surface methodology (RSM) was carried out based on central composite design (CCD). The organic phase consisted of extractant and toluene as diluent. In this process, triethylamine (TEA), di-2-ethylhexyl phosphoric acid and mono-2-ethylhexyl p...

The aim of this work was to develop a new and simple coacervative extraction method for the preconcentration and spectrophotometric determination of Cu(II) in water samples. Dithizone was used as the chelating agent while an anionic surfactant, namely sodium dodecyl sulfate (SDS), was used as extracting agent at room temperature. Central composite design (CCD) based on response surface methodol...

The objective of this paper is simultaneous of aerobic and anaerobic process for phosphorus removal from a dairy wastewater. The system consists of a granular sequencing batch reactor (SBR) working under alternating aerobic/anaerobic conditions. In order to analyze the process, four significant variables viz. MLSS, COD/N ratio, aeration time and cycling time and four dependent parameters as the...

The research extended the work of Chomtee and Borkowski (2012) which compared response surface designs—central composite designs (CCDs), Box-Behnken designs (BBDs), small composite designs (SCDs), Plackett-Burman composite designs (PBDs) and uniform shell designs (USDs)—over a set of reduced models in a spherical design region for five design variables (k = 5) based on the three alphabetic opti...

In this study, biodiesel was produced from underutilized kariya oilseed using ethanol in the presence of pod-husks bio-catalyst. The oil used extracted through soxhlet solvent extraction approach. Transesterification seed investigated Central Composite Design (CCD) Response surface methodology. Process factors such as reaction temperature (65, 70, and 85oC), time (2, 3, 4 h), ethanol/kariya mol...

Abstract A fixed bed pyrolysis reactor was used to pyrolyze Cashew nut shell (CNS). Response Surface Methodology (RSM) then study the process. One Factor at a Time (OFAT) experiment applied using different factors and levels. The OFAT results showed that highest liquid yield 57.8 wt.%. Two levels from each factor were chosen run RSM (applying Central Composite Design (CCD)) by forming two three...

In this study, response surface methodology (RSM) based on central composite design (CCD) was applied for investigation of the effects of ultrasonic waves, temperature and solvent concentration on viscosity reduction of residue fuel oil (RFO). Ultrasonic irradiation was employed at low frequency of 24 kHz and power of 280 W. The results showed that the combination of ultrasonic waves and solven...

The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on the amygdalin content in the extracts was estimated using both mathematical models. The MLP 4-3-1 with exponential function in hidden layer and linear function in output layer ...

Aqueous mixtures of glycerol and 2-hydroxypropyl-β-cyclodextrin (CD), two non-toxic eco-friendly substances, were used as a means of extracting antioxidant polyphenols from oak acorn (Quercur robur) husks. The process was optimized by implementing a central composite (Box-Behnken) experimental design and response surface methodology, taking into consideration the critical parameters (independen...

Composition of culture medium for mass production of Mycoplasma hyopneumoniae was optimized using a response surface methodology (RSM). Initially, the influence of glucose, thallium acetate, fresh yeast extract, horse serum, and porcine serum on the production of mycoplasmal protein was assessed using a 'one factor at a time' technique. Next, factors with a significant effect, including fresh y...