The establishment and maintenance of characteristic cellular morphologies is a fundamental property of all cells. Here we describe Schizosaccharomyces pombe Pal1p, a protein important for maintenance of cylindrical cellular morphology. Pal1p is a novel membrane-associated protein that localizes to the growing tips of interphase cells and to the division site in cells undergoing cytokinesis in a...

Mitochondria undergo continual cycles of fusion and fission, and the balance of these opposing processes regulates mitochondrial morphology. Paradoxically, cells invest many resources to maintain tubular mitochondrial morphology, when reducing both fusion and fission simultaneously achieves the same end. This observation suggests a requirement for mitochondrial fusion, beyond maintenance of org...

ABSTRACT Nervous system development and plasticity involve changes in cellular morphology, making morphological analysis a valuable exercise the study of nervous development, function disease. Morphological is time-consuming requiring meticulous manual tracing contours extensions. We have developed software tool, called SMorph, to rapidly analyze morphology cells system. SMorph performs complet...

Lukasz Swiech,1 Magdalena Blazejczyk,1,2 Malgorzata Urbanska,1 Patrycja Pietruszka,1 Bjorn R. Dortland,3 Anna R. Malik,1 Phebe S. Wulf,3,4 Casper C. Hoogenraad,3,4 and Jacek Jaworski1 1Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland, 2Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland, 3Department of Ne...