This article analyzes the statistical data on colorectal cancer in Russia and world, including incidence, mortality survival. The main pathways of carcinogenesis, molecular subtypes their influence difference lesions proximal distal large intestine are presented. paper provides an overview leading chemotherapy agents targeted therapy cancer, as well reasons for development therapeutic resistanc...

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, metabolism and export of drugs at the cellular levels. While most research has focused on tumor cell autonomous mechanisms of chemoresistance, the tumor microenvironment has e...

Acoustofluidics leads to innovative methods for cellular levitation that can help Raman biospectroscopy avoid spurious substrate signals while keeping cells alive within a controlled microenvironment. In article number 2100552, Harrisson D. A. Santos, Uéslen Rocha, Glauber T. Silva and co-workers present 3D-printed acoustofluidic device allows single-cell analysis with preferred quality over or...

Cancers evolve as a result of the accelerated proliferation cancer cells in complicated, enriched, and active microenvironment. Tumor microenvironment (TME) components are master regulators any step development. The tumor is composed many cellular noncellular that contribute to evolution cells. Cancer-associated fibroblasts (CAFs) activated TME implicate progression metastasis dissemination thr...

The tumor microenvironment (TME) greatly influences the proliferation and progression of HNSCC. Hence, an in depth understanding vivo TME is crucial recapitulating like pathophysiology vitro, still remains a challenge. 3D bioprinted models are increasingly researched on due to their ability precisely replicate cellular organization as seen vivo. This project attempts HNSCC vitro via bio printin...

Cancer cells actively release exosomes carrying specific cellular components, such as proteins, mRNA, and miRNA, to communicate with various cells in the tumor microenvironment. We visualized exosome-mediated transfer of miR-210 from hypoxic breast cancer cells to neighboring cells using a miR-210 specific reporter system. By in vitro and in vivo visualization, we found that exosomes with miR-2...

Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, including mesenchymal stem cells (MSCs) and their progeny, play a pivotal role in the evolution an...

Multiple myeloma (MM) is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow (BM). The progression, from early stages disease as monoclonal gammopathy undetermined significance (MGUS) and smoldering multiple (SMM) to MM occasionally extramedullary disease, drastically affected tumor microenvironment (TME). Soluble factors direct cell–cell interactions r...

The role of the cellular microenvironment in enabling metazoan tissue genesis remains obscure. Ctenophora has recently emerged as one of the earliest-branching extant animal phyla, providing a unique opportunity to explore the evolutionary role of the cellular microenvironment in tissue genesis. Here, we characterized the extracellular matrix (ECM), with a focus on collagen IV and its variant, ...