نتایج جستجو برای: cell receptor

تعداد نتایج: 2070815  

Karimi, Mohammad Hossein, Moazeni, Seyed Mohamad, Mokhtariazad, Talat, shariat, Afsson, Yaghobi, Ramin,

Background & Objectives: Interaction of cytomegalovirus glycoprotein B with toll-like receptors of dendritic cells leads to early signaling and innate immune responses. The aim of this study is to evaluate the effects of cytomegalovirus glycoprotein B on the maturation and function of monocyte-derived dendritic cells in treated groups in comparison with control groups. Materials & Methods: Bloo...

ژورنال: دانشور پزشکی 2011
آزاد منش, کیهان , جعفری, فرنوش , خالقی, سپیده , رسایی, محمد جواد , رهبری‌زاده, فاطمه ,

Background and Objective: Chimeric antigen T cell receptors provide a good approach for adoptive immunotherapy of cancer. In this new kind of chimeric T cell receptor, nanobodies are replaced as variable fragment of T cell receptor. Nanobodies (VHH) are the smallest fragments of antibodies that have great homology to human VH and low immunogenic potential. VHH-hing-CD28-CD3و construct was made ...

Journal: :Pharmaceutics 2021

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions immune receptors (T-cell receptor, TCR or B-cell BCR) context T- leukaemia lymphoma are target...

Journal: :iranian journal of nuclear medicine 2008
mostafa gandomkar reza najafi mohammad mazidi mostafa goudarzi seyed esmaeil sadat ebrahimi

introduction: over expression of selected peptide receptors in human tumors has been shown to represent clinically relevant targets for cancer diagnosis and therapy. the aim of this work was to investigate neuropeptide y (npy) as a new radiopharmaceutical for diagnosis of breast cancer. methods: a neuropeptide y analogues with y1 receptor preference and agonistic properties was synthesized by s...

Journal: :Journal of the Indian Institute of Science 2021

T lymphocytes (T cells) are the major mediators of adaptive immune response. They detect pathogens primarily via interaction their cell receptor (TCR) with cognate pathogen-derived peptide displayed in context MHC on infected cell. A critical step activation is formation immunological synapse, a specialized cell–cell conjugate interface between and cell, where massive TCR-induced actin remodeli...

Journal: :galen medical journal 0
seyed abbas mirmalek department of surgery, islamic azad university, tehran medical sciences branch, tehran fatemeh elhamkani tehran university of medical sciences and health services, shariati hospital, tehran seyed alireza salimi tabatabaee students' research committee, islamic azad university, tehran medical sciences branch, tehran hossein mahmoodzadeh tehran university of medical sciences and health services, shariati hospital, tehran yekta parsa students' research committee, islamic azad university, tehran medical sciences branch, tehran soheila yadollah-damavandi students' research committee, islamic azad university, tehran medical sciences branch, tehran

human epidermal growth factor receptor-2 (her-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. about 280 articles were reviewed and 115 were referred in this review article on her-2. her-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. overexpression results in aggressive behavior, ...

Journal: :iranian journal of allergy, asthma and immunology 0
a. farhondi n. barzargan s. arshi z. pourpak

we have reviewed the medical records of 40 patients with disseminated (bacille calmette-guerin) bcg from 1996 to 1999 in the immunology department of the children hospital, medical center, tehran university. these patients are divided in to 3 groups: 1. patients who had disseminated (bacille calmette-guerin) bcg after vaccination and their diagnosis was chronic granulomatous disease. 2. patient...

Journal: :IUPHAR/BPS guide to pharmacology CITE 2023

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on [113]) are activated endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of complement cascade. C5a exert their functions through binding to (C3a receptor, receptor 1 2), causing cell recruitment triggering cellular degranulation that contributes local inflammation.

Background and Objectives: Alzheimerchr('39')s disease (AD) is a neurodegenerative disease which is marked by impaired cholinergic function and decreased nicotinic acetylcholine receptor (nAChRs) density. nAChRs are important mediators of cholinergic signaling in modulation of learning and memory function. In Alzheimer hippocampus is particularly vulnerable to specific degenerative processes an...

Journal: :iranian journal of immunology 0
natarajan sudhakar dept of molecular oncology nirmala karunakaran nancy dept of molecular oncology kamalalayam raghavan rajalekshmy dept of hematology and immunology, cancer institute (wia), 38, sardar patel road, chennai 600036 thangarajan rajkumar dept of molecular oncology

background: precursor b-acute lymphoblastic leukemia (precursor b-all) oc-curs due to the uncontrolled proliferation of b-lymphoid precursors arrested at a par-ticular stage of b-cell development. precursor-b-all is classified mainly into pro-b-all, common-all and pre-b-all. the common acute lymphoblastic antigen cd10 is the marker for common-all. objective: this study was aimed to examine the ...

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