Random peptide libraries displayed on the ribosome are becoming a new tool for the in vitro selection of biologically relevant macromolecules, including epitopes, antagonists, enzymes, and cell-surface receptors. Ribosome display is a cell-free system of coupling individual nascent proteins (phenotypes) to their corresponding mRNA (genotypes) by the formation of stable protein-ribosome-mRNA com...

An increasing number of studies suggest the importance of antibodies in the pathogenesis of most systemic and organ-specific autoimmune diseases, although there is considerable controversy over the precise role of the autoantibodies involved. In humans, a major obstacle to progress is the identification and cloning of the relevant autoantibodies and autoantigens. Here, an approach based on the ...

Surface immunoglobulin D (IgD)-positive lymphocytes precoated with monoclonal anti-delta antibody were selectively removed from blood mononuclear cell preparations by "panning" and by fluorescence-activated cell sorter. The depletion of sIgD+ cells did not significantly affect plasma cell responses to pokeweed mitogen PWM). PWM-responsive B cells lacking sIgD and mouse erythrocyte receptors pre...

We present an instrument that explores an algorithmic sound spatialization system developed with the SuperCollider programming language. We consider the implementation of spatial multidimensional panning through the simultaneous use of polygonal shaped horizontal and vertical loudspeaker array. This framework uses chaotic dynamical systems to generate discrete data series from the orbit of any ...

In this paper, we propose an original method to include spatial panning information when converting monophonic recordings to stereophonic ones. Sound sources are first identified using perceptually motivated clustering of spectral components. Correlations between these individual sources are then identified to build a middle level representation of the analysed sound. This allows the user to de...

Recording engineers, mixers, and producers play important yet often overlooked roles in defining the sound of a particular record, artist, or group. The placement of different sound sources in space using stereo panning is an important component of their work. Stereo panning information typically is not utilized in music information retrieval (MIR) tasks such as genre and artist classification....

Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...

Software to display DNA sequences is a crucial tool for bioinformatics research. This study examined techniques for navigating large DNA sequences via panning and zooming. This involved surveying the navigation facilities of current bioinformatics applications and performing a heuristic analysis on the most common interface controls found. Several prototypes for sequence navigation via panning ...