Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus human T-cell lymphotrophic virus-I (HTLV-I). It is an aggressive leukemia with an overall mortality rate of 50% within 5 months; no conventional chemotherapy regimen appears successful in inducing long-term disease-free survival in ATL patients. However, ATL cells constitutively express high-affinity inte...

background: sodium valproate, an anticonvulsant drug, is reported to stimulate human immunodeficiency virus type 1 and human cytomegalovirus replication. since epileptic patients undergoing sodium valproate therapy may suffer from various virus infections, the effect of this drug on replication of viruses especially those affecting neuronal tissues such as herpes simplex virus type 1 is worthy ...

1 International Agency for Research on Cancer. Human immunodeficiency viruses and human T-cell lymphotrophic viruses. Lyons: IARC, 1996. (IARC Monographs on the Evaluation of Carcinogenic Risk to Humans, Vol 67.) 2 Kaplan JE, Osame M, Kubota H, Igata I, Nishitani H, Maeda Y, et al. The risk of development of HTLV-I associated myelopathy/tropical spastic paraparesis among persons infected with H...

Background: The human T-cell lymphotropic virus type I is the first retrovirus idenfied in humans. The virus has been associated with adult T-cell leukemia/lymphoma, human T-lymphotropic virus type I, myelopathy/tropical spasc paraparesis, uveis, arthris, pulmonary lymphocyc alveolis, keratoconjuncvis sicca, and infecous dermas. Human T-lymphotropic virus type Iis endemic in Japan...

background: the human t-cell lymphotropic virus type i is the first retrovirus idenfied in humans. the virus has been associated with adult t-cell leukemia/lymphoma, human t-lymphotropic virus type i, myelopathy/tropical spasc paraparesis, uveis, arthris, pulmonary lymphocyc alveolis, keratoconjuncvis sicca, and infecous dermas. human t-lymphotropic virus type iis endemic in japan, p...

Receptor-mediated internalization and degradation of IL-2 were investigated in cell lines carrying human T cell leukemia/lymphoma (lymphotrophic) virus type I (HTLV-I) and PHA-treated normal PBL. The HTLV-I-carrying cell lines ILT-Yan and TL-Mor, and the PBL expressed both high- and low-affinity IL-2-R. However, another HTLV-I-carrying T cell line, MT-1, expressed mainly low-affinity receptors....