Primary cutaneous lymphomas, which are diagnosed with only skin involvement, can be of B or T cell origin. Due to their varied origin as well diverse presentations, these groups have been divided further into more descriptive and representative groups. The subtypes primary marginal zone lymphoma (PCMZL), follicle center (PCFCL), diffuse large lymphoma, leg type (PCDLBCL-LT) intravascular B-cell...

colorectal lymphoma is an extremely rare disease, representing less than 0.5% of all primary colorectal neoplasms. the disease is usually diagnosed in the advanced stages because of its primary non-specific symptoms. the most common involved site is cecum followed by rectum and ascending colon. diffuse large b-cell lymphoma is a more frequent subtype. although surgical resection is often techni...

The clinical and biological significance of programmed death-1 (PD-1) expression by B-lymphoma cells is largely unknown. Here, using multicolor immunofluorescent staining (MC-IF), we investigated PD-1 PD-L1 in PAX5+ (B-lymphoma), CD68+ (macrophage), or CD3+ (T-cell) formalin-fixed, paraffin-embedded samples 32 consecutive patients with de novo diffuse large B-cell lymphoma (DLBCL) treated ritux...

Diffuse Large B-Cell Lymphoma is characterized by the infiltration of small vessels lymphoid cells. These cells are not seen in systemic circulation. Depending on involvement location, it may present with different clinics such as central nervous system and skin involvement. Therefore, diagnosis delay. Diagnosis based pathology. Herein we a rare patient who initially presented cellulitis was ul...

autoimmune hemolytic anemia (aiha) is characterized by shortening of red blood cell (rbc) survival and the presence of autoantibodies directed against autologous rbcs. approximately 20% of autoimmune hemolytic anemia cases are associated with cold-reactive antibody. about half of patients with aiha have no underlying associated disease; these cases are termed primary or idiopathic. secondary ca...

Peritoneal lymphomatosis is an extremely rare presentation of lymphoma. Due to its relative low frequency, it receives much less attention than peritoneal carcinomatosis. The challenge is to differentiate between lymphomatosis and carcinomatosis, as well as peritoneal tuberculosis or other pathologic entities within the peritoneal cavity based essentially on radiologic features. 18</...

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions immune receptors (T-cell receptor, TCR or B-cell BCR) context T- leukaemia lymphoma are target...

Immunoproliferative small intestinal disease (IPSID) is the syndrome associated with Mediterranean lymphoma (a rare form of non-Hodgkin’s lymphoma). Many of the patients diagnosed with secretory IPSID have variable level of abnormal immunoglobulins in serum or other bodily fluids, identified as truncated alpha heavy chain globulins. Most cases are characterized by a loss of ability to synthesiz...

Myeloid sarcoma of female breast is a rare presentation of acute myeloid leukemia (AML). The tumor mass may precede or occur concurrently with AML, CML, myeloproliferative disorders, and/or myelodysplastic syndromes. Histologically, it looks like a large cell lymphoma and can be misdiagnosed. A case refe...