The combination of nanomaterials and stem cell research offers new approaches for the treatment various cardiovascular diseases since regeneration ability tissues is quite limited compared to other organs.

Single cell technology has been widely used in developmental and stem cell biology. In mouse, single cell transcriptome has revealed the cell lineage specification in pre-implantation and post-implantation stage embryo. Now Mohammed et al. investigated the dynamic cell fate commitment during the transition from peri-implantation to early post-implantation stage with single cell RNA sequencing. ...

CD19 is expressed on B- lineage cells and follicular dendritic cells and plays a key role in B cell malignancies and autoimmune diseases. Thus, it has been considered as potential target for several monoclonal antibodies (mAbs). For decades, chemotherapy has been known as one of the major antitumor therapies eradicating high proliferative tumor cells. But, anti- CD19 mAbs developed for treating...

Single-cell gene expression data provide invaluable resources for systematic characterization of cellular hierarchy in multi-cellular organisms. However, cell lineage reconstruction is still often associated with significant uncertainty due to technological constraints. Such uncertainties have not been taken into account in current methods. We present ECLAIR (Ensemble Cell Lineage Analysis with...

T-cell acute lymphoblastic leukemia is an aggressive hematologic malignancy which is usuallyassociated with unfavorable prognosis particularly in patients with refractory/relapsed disease.Therefore, development of novel therapeutic strategies is highly required for improving theoutcome of these patients. Although there are several studies evaluating the efficacy of proteasome<...

Abstract B lymphocyte development is dependent on the interplay between chromatin landscape and lineage-specific transcription factors. It has been suggested that lineage commitment associated with major changes in nuclear environment, proposing a critical role for factors formation of epigenetic landscape. In this report, we have used chromosome conformation capture combination assay transposa...

Recent advances in single-cell technologies have enabled the profiling of genome, epigenome, transcriptome and proteome, along with temporal spatial information individual cells. These provided unique opportunities to understand mechanisms underpinning immune system, such as characterizations molecular cell state, how state evolves its lineage impact location on state. In this review, we discus...