We studied whether the Etest can be used as an alternative to agar dilution to determine antimicrobial susceptibilities of ceftriaxone, cefixime, and cefpodoxime in Neisseria gonorrhoeae surveillance. One hundred fifteen clinical and laboratory isolates of N. gonorrhoeae were tested following the Clinical Laboratory Improvement Amendments (CLIA)-approved CLSI standard agar dilution method and, ...

The objectives of this study were to fabricate cefixime-loaded chitosan microspheres with the ultimate goal of prolonging drug release and to analyze the influence of various process variables on the properties of microspheres such as mode of drug release. The cefixime-loaded chitosan microspheres were fabricated using a coacervation technique. Various process variables like volume of solvent f...

A small GTP-binding protein, Rab8, is essential for apical localization of oligopeptide transporter PEPT1/SLC15A1 and sodium/glucose cotransporter SGLT1/SLC5A1 in small intestine; deficiency of rab8 gene results in mislocalization and reduced expression of these transporters. Here, we examined the role of PEPT1 and SGLT1 in vivo in gastrointestinal absorption of a beta-lactam antibiotic, cefixi...

The biliary excretion profile of cefixime was studied in 10 patients provided with T-tube drainage of the common bile duct after cholecystectomy. Following a single 200-mg oral dose, the peak concentration of cefixime in bile reached 56.9 +/- 70 mg/liter, approximately 20 times as high as the peak concentration in serum, 2.3 +/- 0.85 mg/liter. Cefixime levels in bile proved relatively sustained...

A simple, rapid, accurate and precise RP-HPLC method has been developed and validated for simultaneous estimation of Cefixime and Moxifloxacin in combined tablet dosage form. The chromatographic separation was carried out on Hypersil BDS C18 column (100 x 4.6 mm; 3 μ) with a mixture of phosphate buffer pH 6.0: acetonitrile (75: 25 V/V) as a mobile phase; at a flow rate of 1.0 mL/min. UV detecti...

Abstract—Cefixime, a BCS class II drug, is insoluble in water but freely soluble in acetone and in alcohol. The aqueous solubility of cefixime in water is poor and exhibits exceptionally slow and intrinsic dissolution rate. In the present study, cefixime and βCyclodextrin (β-CD) solid dispersions were prepared with a view to study the effect and influence of β-CD on the solubility and dissoluti...

The title compound, (C(4)H(8)N(3)O)(H(3)O)[Ni(C(7)H(3)NO(4))(2)]·3H(2)O, exhibits isotypism with its Co(II) analogue. All intramolecular distances and angles are similar for the two structures. This applies also for the intermolecular forces, consisting of O-H⋯O and N-H⋯O hydrogen bonds and π-π interactions [with centroid-centroid distances of 3.428 (2) and 3.579 (2) Å], that lead to a cohesion...

In the title compound, (C(3)H(12)N(2))[Zr(C(7)H(3)NO(4))(3)]·3H(2)O, the Zr(IV) cation is chelated by three pyridine-2,6-dicarboxyl-ate anions in a distorted tricapped trigonal-prismatic environment. The crystal structure is stabilized by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.

The organic cation in the title compound, C(24)H(32)N(4) (2+)·2Cl(-)·3H(2)O, is situated on an inversion centre. The cations, anions and water mol-ecules are linked via N-H⋯O, N-H⋯Cl, O-H⋯O and O-H⋯Cl hydrogen bonds and C-H⋯π interactions, forming a three-dimensional framework.