Endotoxin is one of the principal components of grain dust that causes acute reversible airflow obstruction and airway inflammation. To determine whether endotoxin responsiveness influences the development of chronic grain dust-induced airway disease, physiological and airway inflammation remodeling parameters were evaluated after an 8-wk exposure to corn dust extract (CDE) and again after a 4-...

Cell cycle-dependent gene expression is often controlled on the transcriptional level. Genes like cyclin B, CDC2 and CDC25C are regulated by cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) promoter elements mainly through repression in G(0)/G(1). It had been suggested that E2F4 binding to CDE sites is central to transcriptional regulation. However, some promoters a...

The cdc25C phosphatase participates in regulating transition from the G2 phase of the cell cycle to mitosis by dephosphorylating cyclin-dependent kinase 1. The tumor suppressor p53 down-regulates expression of cdc25C as part of G2/M checkpoint control. Transcription of cdc25C oscillates during the cell cycle with no expression in resting cells and maximum transcription in G2. We had identified ...

The initial draft of this commentary was prepared by William Harper MD, FRCPC, Maureen Clement MD, CCFP, Ronald Goldenberg MD, FRCPC, FACE, Amir Hanna MB, BCh, FRCPC, FACP, Andrea Main BScPhm, CDE, Ravi Retnakaran MD, MSc, FRCPC, Diana Sherifali RN, PhD, CDE, Vincent Woo MD, FRCPC, Jean-François Yale MD, CSPQ, FRCPC, and Alice Y.Y. Cheng MD, FRCPC on behalf of the Steering Committee for the Can...

The chronic degenerative endometritis (CDE) is recognised as directly related to age and infertility in the mare. In this study, 14 days post ovulation (PO) pregnancy rate was assessed 60 barren mares affected by CDE, submitted platelet-rich-plasma intrauterine infusion (PRPI) 24 hours PO. Data showed a significant positive effect of PRPI on chance become pregnant Kenney I-II CDE. overall PO 75...

Numerous lattice Boltzmann (LB) methods have been proposed for solution of the convection–diffusion equations (CDE). For the 2D problem, D2Q9, D2Q5 or D2Q4 velocity models are usually used. When LB convection–diffusion models are used to solve a CDE coupled with Navier–Stokes equations, boundary conditions are found to be critically important for accurately solving the coupled simulations. Foll...

It can be painfully hard to take software that runs on one person’s machine and get it to run on another machine. Online forums and mailing lists are filled with discussions of users’ troubles with compiling, installing, and configuring software and their myriad of dependencies. To eliminate this dependency problem, we created a system called CDE that uses system call interposition to monitor t...

The late S/G2-specific transcription of the human cdc25C gene is dependent on an initiator-proximal repressor element (CDE) and an upstream activating sequence (UAS) of undefined nature. We now show that these upstream sequences harbour multiple in vivo protein binding sites that interact with transcriptional activators and form separable, context-independent functional modules. Major component...

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