Human natural regulatory CD4+ T cells comprise 5–10% of peripheral CD4+T cells. They constitutively express the IL-2R??chain (CD25) and nuclear transcription Foxp3. These are heterogeneous contain discrete subsets with distinct phenotypes functions. Studies in mice report that LAG-3 has a complex role cell homeostasis is expressed CD4+CD25+ In this st...

multiple sclerosis (ms) is a complex neurological disease and its prevalence is about 2 million in the world. neuroinflammation plays a key role in ms. vitamins are essential nutrients that have effective role on immune system including activation of lymphocyte and differentiation of t-helper cell. vitamin d is a micronutrient that is effective on immune function. deficiently of vitamin d is a ...

background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...

patients and methods in this cross-sectional study, peripheral mononuclear cells (pbmcs) were isolated from peripheral blood of 29 patients with newly diagnosed pulmonary tb and 19 patients with positive tuberculin skin test. the pbmcs were activated with ppd for 72 hours. activated cells were harvested, rna was extracted and cdna was synthesized. a real-time taqman method was designed and opti...

Sezary syndrome (SS) is the leukemic variant of CD4+ cutaneous T-cell lymphoma. Mogamulizumab an FDA-approved monoclonal antibody targeting surface CCR4 on SS cells. We’ve previously described highly expressed biomarker genes and altered cytokine gene expression that favors a Th2-immune phenotype. Here we evaluated mogamulizumab’s efficacy in reducing malignant T-cells, decreasing expression, m...

HCV infection has been hypothesized as a contributor of poor CD4+ recovery in patients living with HIV (PLWHIV). Aim this study was to evaluate CD4+, CD8+ cells and CD4/CD8 ratio trends before after treatment direct acting agents (DAA) PLWHIV. HIV/HCV enrolled ICONA HepaICONA cohorts HIV-RNA?50 copies/ml who achieved sustained viral response DAA were studied. A linear regression model used inve...

idiopathic cd4+ lymphocytopenia is a rare combined immunodeficiency disease, characterized by low cd4+ t-cell count and increased susceptibility to opportunistic infections, autoimmunity and malignancies after exclusion of secondary forms of cd4 lymphocytopenia. here we present a 13-year old boy who was referred to our center because of destructive ulceration of soft and hard palates with exten...