DNA polymerases can misinsert ribonucleotides that lead to genomic instability. DNA polymerase β discourages ribonucleotide insertion with the backbone carbonyl of Tyr-271; alanine substitution of Tyr-271, but not Phe-272, resulted in a >10-fold loss in discrimination. The Y271A mutant also inserted ribonucleotides more efficiently than wild type on a variety of ribonucleoside (rNMP)-containing...

1589. Lunar and Planetary Institute, Houston. [CD-ROM] Zuber, M. T., D. E. Smith, R. J. Phillips, S. C. Solomon, W. B. Banerdt, G. A. Neumann, and O. Aharonson 1998a. Shape of the northern hemisphere ofET AL. Mars from the Mars Orbiter Laser Altimeter (MOLA). Geophys. Res. Lett.25, 4393–4396. Zuber, M. T., D. E. Smith, S. C. Solomon, J. B. Ashire, R. S. Azfal, O. Aharonson, K. Fishbaugh...

Ryoichi Nakazawa, MD, Department of Nephrology, Tokatsu Clinic Hospital, 822 Hinokuchi, Matsudo 271 (Japan) Dear Sir Endotoxin (lipopolysaccharide, LPS) exists in the dialysate and is closely associated with the pathophysiology of dialysis-related amyloidosis [1]. LPS binds to LPS-binding protein (LBP), and the complex binds to CD 14 on the surface of mature monocytes. CD 14, the receptor of th...

25, ISSUE 4, PP. 271–283, ISSN 0730-7829, ELECTRONIC ISSN 1533-8312 © 2008 BY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA. ALL RIGHTS RESERVED. PLEASE DIRECT ALL REQUESTS FOR PERMISSION TO PHOTOCOPY OR REPRODUCE ARTICLE CONTENT THROUGH THE UNIVERSITY OF CALIFORNIA PRESS’S RIGHTS AND PERMISSIONS WEBSITE, HTTP://WWW.UCPRESSJOURNALS.COM/REPRINTINFO.ASP. DOI:10.1525/MP.2008.25.4.271 Pitch and Time ...

II1. Regu la t ion of t r anspor t ac t iv i ty by amino acid avai lab i l i ty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269 A, Regula t ion of System A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269 B. Regula t ion of System L . . . . . . . . . . . . . . ....

A method for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP), based on a direct determination of SMX after diazotization and coupling with 2-naphthol by visible spectrophotometry and an indirect determination of TMP in the UV region by difference was developed. By the suggested procedure, it was possible to analyze SMX and TMP in pharmaceutical preparations witho...

A method for the simultaneous determination of sulfamethoxazole (SMX) and trimethoprim (TMP), based on a direct determination of SMX after diazotization and coupling with 2-naphthol by visible spectrophotometry and an indirect determination of TMP in the UV region by difference was developed. By the suggested procedure, it was possible to analyze SMX and TMP in pharmaceutical preparations witho...

Indolicidin is a 13-residue antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils that contains five Trp and three Pro residues. Falla et al. [(1996) J. Biol. Chem. 271, 19298] suggested that indolicidin forms a poly-L-proline II helix based upon the circular dichroism (CD) spectra of a closely related peptide (indolicidin methyl ester). In contrast, we found ...

This paper introduces Quantian, a scientific computing environment. Quantian is directly bootable from cdrom, self-configuring without user intervention, and comprises hundreds of applications, including a significant number of programs that are of immediate interest to quantitative researchers.

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