Pigs infected with Ascaris suum or controls were given 100 microg (low-dose) or 1,000 microg (high-dose) all-trans retinoic acid (ATRA)/kg body weight in corn oil or corn oil alone per os on days after inoculation (DAI) -1, +1, and +3 with infective eggs. Treatment with ATRA increased interleukin 4 (IL4) and IL12p70 in plasma of infected pigs at 7 DAI and augmented bronchoalveolar lavage (BAL) ...

Monocytes/macrophages (MOs/MΦs) are suggested to be crucial for skeletal muscle repair and remodeling. This has been attributed to their proangiogenic potential, secretion of growth factors, and clearance of tissue debris. Skeletal muscle injury increases the number of MΦs in the tissue, and their importance for muscle regeneration has been supported by studies demonstrating that depletion of M...

BACKGROUND In vitro polarized human Th2 cells preferentially express the chemokine receptors CCR3 and CCR4 and migrate to their ligands: eotaxin, monocyte-derived chemokine (MDC) or CCL22, thymus- and activation-regulated chemokine (TARC) or CCL17. However little is known about the regulation of these chemokine receptor axes by Der p 1-pulsed dendritic cells in house dust mite (HDM)-sensitive a...

The chemokine receptor CCR4 mediates CCL17- and CCL22-driven chemotaxis of Th2 cells into the skin patients with atopic dermatitis (AD). RPT193 is an oral inhibitor that has been developed to treat AD other allergic inflammatory diseases. safety efficacy as monotherapy for moderate-to-severe was previously described in a placebo-controlled, double-blinded Phase 1 study. Here, we present periphe...

c-c motif chemokine 22 (ccl22) c16a genetic variation (rs4359426) and c-c chemokine receptor type 4 (ccr4) c1014t variation (rs2228428) have been suggested to affect the expression level of the cognate proteins. here we tried to investigate the plausible association of these polymorphisms with development of colorectal cancer. 165 patients with colorectal adenocarcinoma (age 54.4±13.4) and 150 ...