Abstrak : Tapak dara (Catharanthus roseus)merupakan obat tradisional, dimana ekstrak baik dari daun ataupn bunga digunakan sebagai oleh masyarakat pedesaan. Perlu dianalisis sifat gel etanol yang dihasilkan yaitu penampakan etanol, viskositas, uji pembakaran, nilai kalor, panas dipindahkan, dan analisis warna api sehingga bisa kelihatan sediaan terbaik untuk menghasilkan etanol. Penelitian bers...

Catharanthus roseus is an important medicinal plant, which produces a variety of indole alkaloids of significant pharmaceutical relevance. In the present study, we aimed to investigate the potential stress-induced increase of indole alkaloid biosynthesis in C. roseus using proteomic technique. The contents of the detectable alkaloids ajmalicine, vindoline, catharanthine, and strictosidine in C....

Periwinkle (Catharanthus roseus L.) (Family: Apocyanaceae) is a ornamental plants with great medicinal properties. Although it is represented by seven species, little work has been carried out on its genetic characterization due to non-availability of reliable molecular markers. Simple sequence repeats (SSRs) have been widely applied as molecular markers in genetic studies. With the rapid incre...

Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids isolated from Catharanthus roseus (L.) G. Don leaves extract. Four alkaloids--vindoline I, vindolidine II, vindolicine III and vindolinine IV--...

Human activities like mining, transport, agriculture, industrial waste disposal and military actions release inorganic pollutants in high concentrations that are toxic to natural ecosystems. Heavy metal pollution causes potential ecological risk. Heavy metals like Cadmium (Cd), Lead (Pb) and Chromium (Cr) when present in high concentrations in soil exert potential toxic effects on overall growt...

The present study establishes the analgesic and anti-pyretic activities of the ethanolic extract of leaves of Catharanthus roseus in the models used. Since antipyretic and analgesic activities are commonly mentioned as characteristic of drugs or compounds which have an inhibitory effect on prostaglandin biosynthesis, the yeast induced hyperthermia in rat model was, therefore, employed to invest...

Free radicals play an important role in pathological processes such as aging and developing cancer; hence, natural products inhibit free radical production, and can play an important role in preventing diseases. We aimed to evaluate the scavenging activity of free radicals, reducing power, inhibition of lipid peroxidation and malondialdehyde (MDA) formation, and the antioxidant composition of r...

Free radicals play an important role in pathological processes such as aging and developing cancer; hence, natural products inhibit free radical production, and can play an important role in preventing diseases. We aimed to evaluate the scavenging activity of free radicals, reducing power, inhibition of lipid peroxidation and malondialdehyde (MDA) formation, and the antioxidant composition of r...

Identification of molecular markers of monoterpenoid indole alkaloid (MIA) accumulation in cell-suspension cultures of Madagascar periwinkle (Catharanthus roseus (L.) G. Don) was performed by two-dimensional polyacrylamide gel electrophoresis. Comparison of the protein patterns from alkaloid-producing and non-producing cells showed the specific occurrence of a 28 kDa polypeptide restricted to c...