نتایج جستجو برای: catalytic site
تعداد نتایج: 421428 فیلتر نتایج به سال:
Nicotinamide phosphoribosyltransferase (NAMPT) is highly evolved to capture nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD(+)) pool during ADP-ribosylation and transferase reactions. ATP-phosphorylation of an active-site histidine causes catalytic activation, increasing NAM affinity by 160,000. Crystal structures of NAMPT with catalytic site ligands identify the pho...
The pandemic influenza AH1N1 (2009) caused an outbreak of human infection that spread to the world. Neuraminidase (NA) is an antigenic surface glycoprotein, which is essential to the influenza infection process, and is the target of anti-flu drugs oseltamivir and zanamivir. Currently, NA inhibitors are the pillar pharmacological strategy against seasonal and global influenza. Although mutations...
The binding of the regulatory subunit to the catalytic subunit of protein kinase is known to completely inhibit the catalytic activity by formation of the inactive holoenzyme. Magnetic resonance methods have been used to compare the binding of ADP, Mn2+, and a peptide substrate and substrate analog to the holoenzyme or to the catalytic subunit. ADP and MnADP are found to bind to the holoenzyme ...
Most studies of nucleotide binding to catalytic sites of Escherichia coli betaY331W-F(1)-ATPase by the quenching of the betaY331W fluorescence have been conducted in the presence of approximately 20 mM sulfate. We find that, in the absence of sulfate, the nucleotide concentration dependence of fluorescence quenching induced by ADP, ATP, and MgADP is biphasic, revealing two classes of binding si...
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