Staphylococcus aureus is the leading cause of skin and soft tissue infections. With emergence antibiotic-resistant bacteria, there an unmet clinical need to develop novel therapies treat The inflammasome components involved in response S. stimulation are well established vitro immune cell cultures. However, formation cells during vivo infections not entirely understood. Therefore, we used mouse...

Recently, caspase-2 was shown to act upstream of mitochondria in stress-induced apoptosis. Activation of caspase-8, a key event in death receptor-mediated apoptosis, also has been demonstrated in death receptor-independent apoptosis. The regulation of these initiator caspases, which trigger the mitochondrial apoptotic pathway, is unclear. Here we report a potential regulatory role of caspase-2 ...