نتایج جستجو برای: casecontrol studies
تعداد نتایج: 1426355 فیلتر نتایج به سال:
A recent study used a network modeling strategy to generate a set of genes linked by potential functional associations. The hyaluronan-mediated motility receptor (HMMR) gene was identified as being as functionally associated with BRCA1 and thus a candidate breast cancer gene. SNPs rs10515860, rs299290, and rs7712023 were reported to be significantly associated with breast cancer in a joint anal...
Mouse double-minute 2 homologue (MDM2) is a key negative regulator of p53, a tumor suppressor gene that initiates cell cycle arrest and apoptosis in response to DNA damage and other cellular stresses. A T > G polymorphism found in the promoter region of MDM2 (SNP309) increases MDM2 expression and thereby attenuates p53 activity. We genotyped the MDM2 polymorphism SNP309 in endometrial cancer ca...
Practice of Epidemiology Assessment of the “Case-Chaos”Design as anAdjunct to theCase-Control Design
In 2012, a novel case series method dubbed the “case-chaos” design was proposed as an alternative to casecontrol studies, whereby controls are artificially created by permutating the exposure information of the cases. Our aim in the current work was to further evaluate the case-chaosmethod. Using a theoretical example of 2 risk factors, we demonstrated that the case-chaos design yields risk est...
چکیده در دنیای پیچیده ی امروز، تغییرات زیادی در زندگی بشری در حال وقوع اند و شاهد رقابت های بسیار فشرده ی جوامع در دستیابی به فناوری برتر و قدرت بیشترهستیم. به نظر می رسد که فرد وجامعه مجبورند به طریقی در وضعیت خویش دگرگونی ایجاد کنند تا از قافله ی علم، فناوری، و پیشرفت عقب نمانند. رشته مطالعات ترجمه نیز از این قاعده مستثنا نیست. علی رغم وسعت روز افزون پژوهش در این حوزه و میان رشته ای بودن مطال...
The role of mannose-binding lectin (MBL) deficiency (MBL2 XA/O + O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, another collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analyzed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD...
©FSRH J Fam Plann Reprod Health Care 2009: 35(1) Introduction The relationship between male circumcision and genital human papillomavirus (HPV) infection and cervical cancer has been greatly clarified in recent years. Along with the strong evidence from both observational studies and three randomised clinical trials (RCTs) consistently showing that male circumcision reduces the risk of HIV infe...
Ecologic (aggregate) data are widely available and widely utilized in epidemiologic studies. However, ecologic bias, which arises because aggregate data cannot characterize within-group variability in exposure and confounder variables, can only be removed by supplementing ecologic data with individual-level data. Here the authors describe the two-phase study design as a framework for achieving ...
High frequency of erythrocyte (red blood cell [RBC]) genetic disorders such as sickle cell trait, thalassemia trait, homozygous hemoglobin C (Hb-C), and glucose6-phosphate dehydrogenase (G6PD) deficiency in regions with high incidence of Plasmodium falciparum malaria and casecontrol studies support the protective role of those conditions. Protection has been attributed to defective parasite gro...
In 1985 a paper in this journal analysed an apparent cluster of multiple myeloma in South Cumbria, England. The study was prompted by reports of seven cases of multiple myeloma in Walney Island. This is a small community adjacent to a shipyard that builds nuclear submarines and is 15 miles away from the Sellafield Nuclear Processing Plant. These seven cases occurred over the seven year time per...
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