abstract background: sperm cells extracted from testes (tese) have poor chromatin quality and motility. various substances are used in the laboratory to increase sperm motility and improve the art outcomes; however, there are few research which considered improving both sperm motility and chromatin quality. objective: the aim of this investigation was to evaluate the improvement of the testicul...

In an accompanying publication, we have shown that in most tissues there is an approximate correspondence between levels of carnitine acetyltransferase activity and concentrations of carnitine or acetylcarnitine (1). In addition, this correspondence may generally be related to the magnitude of the increase in fatty acid oxidation elicited by added carnitine in particular tissue preparations (1,...

BACKGROUND This study examined whether carnitine deficiency is a risk factor and should be viewed as a mechanism during the development of gentamicin (GM)-induced ARF as well as exploring if carnitine supplementation could offer protection against this toxicity. METHODS Adult male Wistar albino rats were assigned to one of six treatment groups: group 1 (control) rats were given daily intraper...

Data on the functionalities of L-carnitine on obesity, diabetes, and as an ergogenic aid are summarized as follows: Obesity: Total lipid, triglyceride, and total protein increased during the 3T3-L1 cell differentiation. However, nonesterified carnitine (NEC), acid-soluble acylcarnitine (ASAC), and acid-insoluble acylcarnitine (AIAC) concentrations were lower in the differentiated 3T3-L1 cells. ...

To determine whether accumulation of long-chain acyl carnitine contributes to electrophysiological abnormalities induced by hypoxia, we characterized effects of normoxic and hypoxic perfusion on the subcellular distribution of endogenous long-chain acyl carnitine and transmembrane potentials of cultured rat neonatal myocytes. Hypoxia increased long-chain acyl carnitine more than 5-fold. Sodium ...

PURPOSE Previously we demonstrated expression and localization of carnitine/organic cation transporters, OCTN1 and OCTN2, in human corneal and conjunctival epithelia. The present study aimed to examine the characteristics of L-carnitine transporters in cultured human limbal corneal (HCLE) and conjunctival epithelial (HCjE) cells. METHODS Time-course, Na(+)-dependence, kinetics, energy- and pH...

The aim of this study is to compare the effects Carnitine, Gensing, Dill and Arginine in lipid peroxidation MDA SOD, GSH antioxidant normal experimentally hydrogen peroxide H2O2 induced oxidative.
 Fifty male rats used age 12-14 weeks weights (300-325 g) divided randomly into 10 groups, included 5 each group as following.
 Control, , Carnitine carnitine + Gensing Dill, Dill+ ,Arginine...

It is well documented that high therapeutic doses of oxazaphosphorines, cyclophosphamide (CP) and ifosfamide (IFO), are associated with cardiomyopathy. This study investigated whether oxazaphosphorines alter the expression of organic cation/carnitine transporter (OCTN2) and antioxidant genes and if so, whether these alterations contribute to CP and IFO-induced cardiotoxicity. Adult male Wistar ...

A deletion mutant of Listeria monocytogenes lacking OpuC, an ABC transporter responsible for the uptake of the compatible solute carnitine, was constructed and carnitine transport assays confirmed that carnitine transport was defective in this mutant. However, the mutant retained the ability to derive osmoprotection from carnitine, suggesting the presence of a second uptake system for this comp...

We studied the effect of intravenously infused carnitine (34 mumol.100 g-1.d-1) on protein and branched-chain amino acid (BCAA) metabolism in rats either starved for 3 d or parenterally fed for 7 d. Carnitine infusion did not significantly affect nitrogen balance, protein content of liver and muscle, plasma concentrations of BCAA and branched-chain keto acid, or leucine oxidation and incorporat...