نتایج جستجو برای: cardiosphere derived cells

تعداد نتایج: 1746389  

2013
Tania I. Fuentes Nancy Appleby Eric Tsay J. Julian Martinez Leonard Bailey Nahidh Hasaniya Mary Kearns-Jonker

Although clinical benefit can be achieved after cardiac transplantation of adult c-kit+ or cardiosphere-derived cells for myocardial repair, these stem cells lack the regenerative capacity unique to neonatal cardiovascular stem cells. Unraveling the molecular basis for this age-related discrepancy in function could potentially transform cardiovascular stem cell transplantation. In this report, ...

2012
Patrick Vliet Marie-José Goumans Pieter A Doevendans Joost P G Sluijter

The high occurrence of cardiac disease in the Western world has driven clinicians and cardiovascular biologists to look for alternative strategies to treat patients. A challenging approach is the use of stem cells to repair the heart, in itself an inspiring thought. In the past 10 years, stem cells from different sources have been under intense investigation and, as a result, a multitude of stu...

Journal: :The Journal of Cell Biology 2005
Yuichi Tomita Keisuke Matsumura Yoshio Wakamatsu Yumi Matsuzaki Isao Shibuya Haruko Kawaguchi Masaki Ieda Sachiko Kanakubo Takuya Shimazaki Satoshi Ogawa Noriko Osumi Hideyuki Okano Keiichi Fukuda

Arodent cardiac side population cell fraction formed clonal spheroids in serum-free medium, which expressed nestin, Musashi-1, and multi-drug resistance transporter gene 1, markers of undifferentiated neural precursor cells. These markers were lost following differentiation, and were replaced by the expression of neuron-, glial-, smooth muscle cell-, or cardiomyocyte-specific proteins. Cardiosp...

Journal: :Circulation research 2009
Yao Liang Tang Wuqiang Zhu Min Cheng Lijuan Chen John Zhang Tao Sun Raj Kishore M Ian Phillips Douglas W Losordo Gangjian Qin

Myocardial infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the inefficient recruitment of exogenously administered progenitor cells limits the effectiveness of cardiac cell therapy. Recent reports indicate that interactions between the CXC chemokine stromal cell-derived factor 1 and its receptor CXC chemokine receptor 4 (CXCR4) critically mediate the ischemia-induce...

2011
Carolyn A. Carr Daniel J. Stuckey Jun Jie Tan Suat Cheng Tan Renata S. M. Gomes Patrizia Camelliti Elisa Messina Alessandro Giacomello Georgina M. Ellison Kieran Clarke

AIMS Endogenous cardiac progenitor cells, expanded from explants via cardiosphere formation, present a promising cell source to prevent heart failure following myocardial infarction. Here we used cine-magnetic resonance imaging (MRI) to track administered cardiosphere-derived cells (CDCs) and to measure changes in cardiac function over four months in the infarcted rat heart. METHODS AND RESUL...

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