Salvianolic acid B (SAB, Sal B) is the representative component of phenolic acids derived from the dried root and rhizome of Salvia miltiorrhiza Bge (Labiatae) which has been used widely and successfully in Asian countries for clinical therapy of various vascular disturbance-related diseases for hundreds of years. However, its exact cardioprotective components and the underlying mechanism for t...

Scott K. Powers, Ph.D., Ed.D. Professor Department of Exercise and Sport Sciences and Department of Physiology University of Florida Gainesville, Florida In addition to the cardioprotective effects of regular exercise, there is also a growing interest in nutritional antioxidant supplementation as a strategy to protect the heart during a heart attack. Indeed, the role that dietary antioxidants p...

ATP-sensitive potassium channel (K(ATP)) openers as a class protect ischemic myocardium. The protective effects are independent of vasodilator activity and effects on action potential shortening, actions typically associated with sarcolemmal K(ATP) activation. BMS-191095 is a novel mitochondrial K(ATP) opener which protects ischemic myocardium while having no electrophysiologic or vasodilator e...