Recovery from hypoxia has been shown to prolong cardiac muscle contraction, particularly the relaxation phase. The present studies were designed to examine whether incomplete relaxation between beats can result from this prolongation of contraction and relaxation in isolated muscle after hypoxia and in the canine heart after both hypoxia and acute ischemia. The relationship between heart rate a...

Sustained ventricular tachyarrhythmias represent the most life-threatening disturbance of cardiac rhythm. Many underlying structural heart diseases, generally associated with fibrous scar formation and geometrical alteration of the ventricles, predispose to the reentrant pattern of electrical activation, which is notorious arrhythmic mechanism in these conditions. Continuing ischemia, evolving ...

ATP-sensitive K(+) channels (K(ATP)) are major component of preventing ischemia-reperfusion injury. However, there is little information regarding to the expressional difference of K(ATP) and its function between left and right ventricles. In this study, we measured the lactate dehydrogenase release of rabbit heart slices in vitro and determined the difference of the K(ATP) expression at the bo...

BACKGROUND It was reported that N,N,N'N'-tetrakis-[2-pyridylmethyl]-ethylenediamine (TPEN), a transition metal chelator, confers cardioprotection against myocardial ischemic injury. In this study, we investigated the effect of TPEN targeting reperfusion period in isolated rat hearts. METHODS Langendorff perfused rat hearts were subjected to 30 min of regional ischemia and 2 h of reperfusion. ...

background and objective : sleep deprivation (sd) is caused by a host of reasons and has numerous consequences on cardiac system. in this study, we aimed to assess the preconditioning effects of acute sd on ischemia (is)-induced ventricular arrhythmias in isolated rat hearts. materials and methods : male wistar rats randomly were placed into the four groups: is-group, acute sd group, control gr...

in the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. the hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. in the control group, the hearts were perfused by normal drug free krebs-henseleit (k/h) solution t...

Cardiomyopathies are a group of heart diseases that influence muscles directly and are not related to congenital, valvular, and pericardial diseases (Salehifar et al., 2008). Cardiomyopathies are usually classified on the basis of structural or functional causes. Thus, dilated cardiomyopathy is characterized by an enlarged ventricular chamber size and reduced cardiac contractility, hypertrophic...

Cardiomyopathies are common cardiac disorders that primarily affect cardiac muscle resulting in cardiac dysfunction and heart failure. Transgenic mouse disease models have been developed to investigate the cellular mechanisms underlying heart failure and sudden cardiac death observed in cardiomyopathy cases and to explore the therapeutic outcomes in experimental animals in vivo. Echocardiograph...

Recent studies have shown that heart diseases are always accompanied with high levels of IL-1beta and a decrease in Na+-K+ ATPase concentrations. This work studies the involvement of the cytokine in the observed changes in the pump. Rats were injected intraperitoneally with 400 mg of IL-1beta and 4 h later, the heart was isolated and a crude homogenate of the right and left ventricles was prepa...