The refinement of mechanical cardiac assist devices over the past 50 years largely has been driven by the clinical imperatives to provide reliable circulatory support to patients waiting for cardiac allografts (bridge to transplant) or longterm support for patients with very advanced heart failure (destination therapy). In the course of increasing success with these applications, investigators ...

The concept of the plasticity or transdifferentiation of adult stem cells has been challenged by the phenomenon of cell fusion. In this work, we examined whether neonatal cardiomyocytes fuse with various somatic cells including endothelial cells, cardiac fibroblasts, bone marrow cells, and endothelial progenitor cells spontaneously in vitro. When cardiomyocytes were cocultured with endothelial ...

Little is known about the mechanisms underpinning thermal plasticity of vertebrate hearts. Bluefin tuna hearts offer a unique model to investigate processes underlying thermal acclimation. Their hearts, while supporting an endothermic physiology, operate at ambient temperature, and are presented with a thermal challenge when migrating to different thermal regimes. Here, we examined the molecula...

one of the new research fields in plasticity is related to choosing a proper non-associated flow rule (nafr), instead of the associated one (afr), to predict the experimental results more accurately. the idea of the current research is derived from combining von mises and tresca criteria in the places of yield and plastic potential surfaces in rate-independent plasticity.  this idea is implemen...

ABSTRACT Warming in the region of Western Antarctic Peninsula is occurring at an unprecedented rate, which may threaten survival notothenioid fishes. Herein, we review studies characterizing thermal tolerance and cardiac performance notothenioids – a group that includes both red-blooded species white-blooded, haemoglobinless icefishes as well relevant biochemistry associated with failure during...

a semi-micromechanical multilaminate model is introduced here to predict the mechanical behavior of soils. this model is like a bridge between micro and macro scale upon the satisfaction of minimum potential energy level during any applied stress/strain increments. the concept of this model is based on a certain number of sampling planes which constitute the elastic-plastic behavior of the soil...

Introduction: The effects of cannabinoids (CBs) on synaptic plasticity of hippocampal dentate gyrus neurons have been shown in numerous studies. However, the effect of repeated exposure to cannabinoids on hippocampal function is not fully understood. In this study, using field potential recording, we investigated the effect of repeated administration of the nonselective CB receptor agonist WIN5...