BACKGROUND Iron overload can affect cardiac structure and function by the production of free radicals in addition to iron deposits in heart muscle. The purpose of this study was to compare traditional and non-traditional cardiovascular risk factors (CVRF) in children and adolescents on renal replacement with and without iron overload. Also, we evaluated the relationships between iron overload a...

background transfusion-induced iron overload leads to many complications in patients with β-thalassemia major. this study aimed to compare the level of iron stored in the liver and heart measured by mri t2 * with ferritin levels in these patients. materials and methods this study was done on 52 patients with β-thalassemia major aged 7 to 29 years. serum ferritin level was checked and heart and ...

Background: Iron overload can cause many complications and damage many organs as well as physiologic functions. Consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. The aim of this review is to investigate hydrophilic phytochelators in iron overload condition. Methods: In this review, the possible ...

Hemochromatosis is a clinical syndrome caused by abnormal accumulation of iron in parenchymal organs leading to organ toxicity and dysfunction. Cardiac hemochromatosis is a cardiomyopathy due to primary iron-overload cardiomyopathy which causes congestive heart failure. Patients with cardiac hemochromatosis may be asymptomatic early in the disease. Once heart failure develops, there is rapid de...

Introduction: Thalassemia major (TM) patients require lifelong iron load monitoring to assess the effectiveness of chelation therapies. Multiecho T2* MRI is a well established technique for heart and liver iron overload assessment [1]. There are few reports on the use of MRI to study iron deposits in the pancreas. The aims of this study were to describe the T2* values of the pancreas in patient...

Iron overload is known to occur in the West European and American population due to the consumption of iron-rich diets. On the other hand, genetic disorders leading to iron overload are also known. Iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. In experimental animals iron ...

An 11-year-old boy with Down syndrome and acute lymphoblastic leukemia developed hepatic dysfunction after only 10 months of treatment. MRI revealed severe iron deposition in the liver, pancreas, and heart. In stark contrast to what is seen in hemoglobinopathies, pancreatic and cardiac iron overload occurred with relatively low transfusion exposure and in a very short time period in this patien...

OBJECTIVES To evaluate a population of asymptomatic thalassemia major (TM) and thalassemia intermedia (TI) patients using cardiovascular magnetic resonance (CMR). We supposed that TI group could be differentiated from the TM group based on T2(∗) and that the TI group could demonstrate higher cardiac output. METHODS A retrospective analysis of 242 patients with TM and TI was performed (132 mal...

Dietary copper in the U.S. often is lower than that proved insufficient for men and women under controlled conditions. Iron overload can have adverse effects on copper nutriture and can produce cardiac disease in people. The hypothesis that iron can interfere with copper utilization to produce adverse effects related to cardiovascular function was tested. Rats were fed a diet high in iron and m...

Cardiac iron overload causes most deaths in beta-thalassemia major. The efficacy of deferasirox in reducing or preventing cardiac iron overload was assessed in 192 patients with beta-thalassemia in a 1-year prospective, multicenter study. The cardiac iron reduction arm (n = 114) included patients with magnetic resonance myocardial T2* from 5 to 20 ms (indicating cardiac siderosis), left ventric...