Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α). Materials and Methods: We constructed rat models with myocardial I/R injury and H9C2 cell models with hypoxia/reoxygenation (H/R) damage. Anti-miR-155 and...

Oncostatin M (OSM) exhibits many unique biological activities by activating Oβ receptor. However, its role in myocardial I/R injury in diabetic mice remains unknown. The involvement of OSM was assessed in diabetic mice which underwent myocardial I/R injury by OSM treatment or genetic deficiency of OSM receptor Oβ. Its mechanism on cardiomyocyte apoptosis, mitochondrial biogenesis and insulin se...

OBJECTIVE The study objectives were to assess the efficacy of N,O carboxymethyl chitosan film in reducing postsurgical adhesion in a rabbit cardiac injury model and to confirm the efficacy of N,O carboxymethyl chitosan gel and film in reducing postsurgical adhesion formation in a pig cardiac injury model. METHODS (1) Rabbit cardiac injury model: Cardiac injury was generated by abrading the an...

Cardiac rhythm abnormality is a common finding in patients with leptospirosis. Relative bradycardia, atrial fibrillation, flutter and ventricular premature beats are the arrhythmias seen In present case, patient presented septic shock had fibrillation. Further evaluation revealed hypokalemic acute kidney injury severe metabolic acidosis. The fibrillation reverted to sinus after correction of hy...

BACKGROUND Cardiac arrest is a lethal complication of Nuss repair of pectus excavatum which is strongly related to heart or big vessels injury. A rare case developed cardiac arrest without direct cardiac injury during Nuss procedure is presented in this article. CASE PRESENTATION In July 2015, a previously healthy 18-year-old man undergoing Nuss repair for pectus excavatum developed cardiac a...