From the leaves of Cryptostegia grandiflora, four new cardiac glycosides oleandrigenin 3-O-beta-glucopyranosyl-(1-->4)-beta-cymaropyranosyl-(1-->4)-beta-digitoxopyranoside, cryptostigmin I, oleandrigenin 3-O-beta-glucopyranosyl-(1-->4)-alpha-rhamnopyranoside, cryptostigmin II, 16-propionylgitoxigenin 3-O-beta-glucopyranosyl-(1-->4)-alpha-rhamnopyranoside, cryptostigmin III and oleandrigenin 3-O...

安孫子 保 The work was supported by a grant from the Ministry of Education in Japan. In spite of numerous reports on bradycardia produced by cardiac glycosides hitherto , the mechanism is not completely clarified. Ackermann (1) reported that early digitalis bradycardia was prevented by vagal severance or by administration of atropine. This observation has generally been ac cepted. Heymans and Heyma...

Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunogenic demise of cancer cells, an effect that most likely contributes to their clinical anticancer a...

Two new cardiac glycosides were isolated from the seeds of Erysimum cheiranthoides. Their structures were characterized as strophanthidin glycosides of 3-O-alpha-L-rhamnopyranosyl-(1-->4)-3-O-acetyl-beta-D-digitoxopyranosyl and 3-O-beta-D-glucpyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-3-O-acetyl-beta-D-digitoxopyranosyl.

Plant active metabolites are under intensive examinations around the world to supplement the drugs with minimal side effects. Thus, there is vast potential to explore the possible medicine from the plant sources. Cardiac glycosides are a unique group of secondary metabolites that they are considered one of the most useful drugs in therapeutics. In this review, cardiac glycosides and their analo...

This case report describes several electrocardiographic findings in an 8-years old female Pomeranian dog that was referred with a history of digoxin overdose. Electrocardiographic abnormalities detected in this case could be classified as primary electrocardiographic disturbances, reflecting cardiac chamber enlargement and secondary ECG changes, attributed to digoxin toxicity. ECG manifestatio...

During the last 40 years extensive investigations have been reported on various aspects of the metabolism of cardiac glycosides. A detailed review describing the cellular basis of cardiac glycoside action has been reported by Hajdu and Leonard (1). One prime difficulty encountered in determining the metabolic fate of cardiac glycosides is in establishing a reliable and sensitive method for dete...