Syeda A. Batul, MD, Felix Yang, MD, FHRS, Karan Wats, MBBS, Suvash Shrestha, MBBS, Yisachar J. Greenberg, MD, FHRS From the Cardiology Division, Maimonides Medical Center, Brooklyn, New York, Department of Cardiac Electrophysiology, Montefiore Medical Center, Bronx, New York, Department of Cardiac Electrophysiology, Cardiology Division, and Department of Medicine, Maimonides Medical Center, Bro...

Thyroid hormone exerts numerous effects on the cardiovascular system. Hypothyroidism can lead to various electrocardiographic and mechanical changes in the heart and blood vessels.The potential risk for sudden cardiac death in patients with hypothyroidism have never been properly explored. However, numerous reports of various electrocardiographic changes indicative of such a risk has been publi...

Mathematical modeling has been used for over half a century to advance our understanding of cardiac electrophysiology and arrhythmia mechanisms. Notably, computational studies using mathematical models of the cardiac action potential (AP) have provided important insight into the fundamental nature of cell excitability, mechanisms underlying both acquired and inherited arrhythmia, and potential ...

In this paper, we illustrate how advanced computational modelling and simulation can be used to investigate drug-induced effects on cardiac electrophysiology and on specific biomarkers of pro-arrhythmic risk. To do so, we first perform a thorough literature review of proposed arrhythmic risk biomarkers from the ionic to the electrocardiogram levels. The review highlights the variety of proposed...

Systems biology is currently making a bid to show that it is able to make an important contribution to personalised or precision medicine. In order to do so, systems biologists need to find a way of tackling the pervasive variability of biological systems that is manifested in the medical domain as inter-subject variability. This need is simultaneously social and epistemic: social as systems bi...

We study, by means of the periodic unfolding technique, homogenization a modified bidomain model, which describes propagation action potential in cardiac electrophysiology. Such allowing presence pathological zones heart, involves various geometries and non-standard transmission conditions on interface between healthy damaged part muscle.

No subspecialty in cardiology has undergone a more radical transformation in the last half century than has clinical cardiac electrophysiology. From the creation of the coronary care unit (CCU), with its concept of intensive monitoring of patients who have cardiac arrhythmias, to understanding the genetics of ion channel disturbances responsible for inherited cardiac arrhythmias, clinical cardi...