abstract background iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. severe iron deposition in tissues leads to organ dysfunction. many organs can be affected such as heart, liver, and endocrine organs. cardiac failure and liver fibrosis are the consequent of iron overload in transfusion dependent hemoglobinopathy. magnetic re...

background: the aim of this study was to investigate the correlation between the cardiac and hepatic iron-overload as assessed by magnetic resonance imaging t2 star (mrit 2 -star) technique and serum ferritin level in patients with thalassemia major. methods: in this cross-sectional study we evaluated 170 patients in sayed shohada hospital in isfahan in the year of 2009, cardiac and hepatic iro...

Sphingosine 1-phosphate (S1P) mediates multiple pathophysiological effects in the cardiovascular system. However, the role of S1P signaling in pathological cardiac remodeling following myocardial infarction (MI) remains controversial. In this study, we found that cardiac S1P greatly increased post-MI, accompanied with a significant upregulation of cardiac sphingosine kinase-1 (SphK1) and S1P re...

Sexual activity is a concern both for patients with coronary artery disease and physicians taking care of these patients. Sexual counselling is an important component of treatment for post-myocardial infarction patients. Therefore, it is essential for the cardiologist to understand the physiological and haemodynamic changes that occur during sexual intercourse. It should also be borne in mind t...

Autophagy is important in cells for removing damaged organelles, such as mitochondria. Insufficient autophagy plays a critical role in tissue injury and organ dysfunction under a variety of pathological conditions. However, the role of autophagy in nonlethal traumatic cardiac damage remains unclear. The aims of the present study were to investigate whether nonlethal mechanical trauma may result...

The expert consensus of the Russian communities discusses issues comprehensive medical rehabilitation patients with coronavirus disease 2019 (COVID-19). COVID-19 is a contagious infectious that can cause pulmonary, cardiac, motor, metabolic, neurocognitive and mental disorders, is, multiple organ dysfunction. survivors, especially after severe clinical course, face serious psychological physica...

Objective: Heart failure with preserved ejection fraction is a major health care issue which has been difficult to manage date, due its complex and not well understood pathophysiology. Specifically, if wealth of literature focuses on heart cardiac component, very little information can be found vascular component. Our goal unravel the critical role small vessel disease in pathophysiology diasto...

Background: Hyperthyroid has various effects on the cardiovascular system. Cardiac arrhythmias ranging from sinus tachycardia to atrial fibrillation and low/high cardiac output state congestive heart failure are observed in patients with hyperthyroidism. If hyperthyroidism is recognized treated early, dysfunction could be corrected. This case presentation will discuss importance of thyroid func...

Diastolic dysfunction of the heart is correlated with cardiac mortality. Serum cystatin C (CysC) is an endogenous marker of kidney function. It is not clear whether serum CysC is associated with diastolic dysfunction in patients with varying cardiac conditions with concomitant diastolic abnormalities and preserved ejection fraction (EF). The authors measured serum CysC levels in patients with c...