A 38-year-old male patient presented to our hospital with a 3-month history of shortness of breath in combination with severe peripheral edema and ascites. Twenty-two years previously, he had undergone bioprosthetic tricuspid valve implantation due to Ebstein anomaly. Transthoracic echocardiography revealed significantly dilated right cardiac chambers, reduced right ventricular function, stenot...

OBJECTIVES The purpose of this study was to compare thallium reinjection with standard stress/delay redistribution for the prediction of cardiac events. BACKGROUND Although thallium reinjection enhances the detection of viable myocardium, its contribution to prognosis over stress/delay redistribution in a general referral population has not been clearly evaluated. METHODS This retrospective...

A.A., a man aged 25 years, was found to have a cardiac murmur at the age of 8 years, but he had led a normal active life and has experienced no symptoms of cardiac origin. However, when examined in September, 1960, his heart was found to be moderately enlarged and there was evidence of left ventricular hypertrophy. An electrocardiogram showed a prolonged P-R interval, right bundle-branch block,...

A small ventricular septal defect in an 18 year old man was shown by serial cardiac catheterisation to be associated with a progressive increase in pulmonary arterial pressure. Surgical closure of the defect had no effect on the increased pulmonary arterial pressure. Whether pulmonary hypertension occurred secondary to the haemodynamics of the ventricular septal defect or as an independent even...

A prominent filling defect was depicted on a radionuclide ventriculogram in a patient with mitral regurgitation. This defect was later shown, by cardiac ultrasound, to be due to mitral valve prolapse into the left ventricle during diastole. This case illustrates that mitral valve prolapse should be added to the list of clinical entities that can result in an intraventricular defect on a radionu...

BACKGROUND The SCN5A gene encoding the human cardiac sodium channel alpha subunit plays a key role in cardiac electrophysiology. Mutations in SCN5A lead to a large spectrum of phenotypes, including long-QT syndrome, Brugada syndrome, and isolated progressive cardiac conduction defect (Lenègre disease). METHODS AND RESULTS In the present study, we report the identification of a novel single SC...