Oral cancer is one of the major global threats to public health. The development of oral cancer is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. As, curative therapy available for oral cancer often results in debilitating changes in appearance, speech, swallowing and breathing, preventive strategies are desirable. Chemoprevention , is the u...

BACKGROUND Infections with certain viruses, bacteria, and parasites are strong risk factors for specific cancers. As new cancer statistics and epidemiological findings have accumulated in the past 5 years, we aimed to assess the causal involvement of the main carcinogenic agents in different cancer types for the year 2012. METHODS We considered ten infectious agents classified as carcinogenic...

an alternative in vitro approach to drug screening has been the use of human cell cultures for antiviral agents and microbial cell cultures for the assessment of the carcinogenic potential of selected compounds. a number of protozoan species have been also used as drug screens for anti-protozoal agents. the ciliated protozoan tetrahymena pyriformis species has been widely utilised as a drug scr...

It is well known that different species (8, 14, 35, 36, 44) and different organs and tissues (45) vary greatly in their susceptibility to carcinogenic agents. The only animals that have been extremely susceptible to the induction of tumors by means of physical and pure chemical agents are mice and rats. It has been found difficult and frequently impossible to produce tumors by the same methods ...

Of the many aspects of cancer research, three which are perhaps of particular interest to chem ists are the problems of cell metabolism, of chemo therapy, and of carcinogenesis. All these aspects are closely related, and at the present stage of de velopment of the subject chemotherapy and car cinogenesis are intimately connected, as most of the physical and chemical agents used in therapy of ca...

Mouse models for colon cancer that harbor a germ line mutation in the tumor suppressor gene Adenomatous polyposis coli (Apc) exhibit a primary genetic defect that predisposes to a high incidence of adenomatous polyps in the small intestine rather than in the colon. Colon cell culture models expressing quantifiable markers for carcinogenic risk may represent an alternative approach to reduce, re...

Significantly enhanced attachment to Ehrlich ascites and Escherichia coli cells was observed for radioactive DNA and RNA in the presence of chemical mutagens and ultimate carcinogens. In some instances, formation of nucleic acid-protein adducts by these compounds further (or similarly) enhanced the binding. DNA irradiated with ultraviolet light in the presence of a protein bound more efficientl...

Cholangiocarcinoma (CCA) is the most common cancer in endemic areas of liver fluke infection. Although the liver fluke is recognized as a carcinogenic agent in cholangiocarcinogenesis, other factors may play important roles in bringing about the high prevalence of the cancer in populations of this region. Drug metabolizing enzymes (DME) are essential for detoxification of toxic and carcinogenic...

Ionizing radiation is a well-known carcinogen, and is listed as one carcinogenic agent of occupational cancer. Given the increase in the number of workers exposed to radiation, as well as the increase in concern regarding occupational cancer, the number of radiation-related occupational cancer claims is expected to increase. Unlike exposure assessment of other carcinogenic agents in the workpla...