STUDY OBJECTIVE To investigate oseltamivir and oseltamivir carboxylate pharmacokinetics in critically ill patients who were receiving continuous venovenous hemodialysis (CVVHD) and/or extracorporeal membrane oxygenation (ECMO). DESIGN Prospective, open-label, pharmacokinetic study. SETTING Intensive care units of an academic medical center. PATIENTS Thirteen critically ill patients aged 1...

The equilibrium mixture of yeast enolase with substrate, 2-phospho-D-glycerate (2-PGA), and product, phosphoenolpyruvate (P-enolpyruvate), has been crystallized from solutions of poly(ethylene glycol) (PEG) at pH 8.0. Crystals belong to the space group C2 and have unit cell dimensions a = 121.9 A, b = 73.2 A, c = 93.9 A, and beta = 93.3 degrees. The crystals have one dimer per asymmetric unit. ...

The anaerobic bacterium Syntrophus aciditrophicus metabolized benzoate in pure culture in the absence of hydrogen-utilizing partners or terminal electron acceptors. The pure culture of S. aciditrophicus produced approximately 0.5 mol of cyclohexane carboxylate and 1.5 mol of acetate per mol of benzoate, while a coculture of S. aciditrophicus with the hydrogen-using methanogen Methanospirillum h...

In this study, we synthesized two novel carboxylic acid and carboxylate compounds, both of which had an amide group linked with an azomethine moiety to introduce photoinduced switching of the intramolecular NH...O hydrogen bond. We suggest that the cis-carboxylate compound forms a stronger intramolecular NH...O hydrogen bond than the cis-carboxylic acid compound.

Alkylation reactions of α-carboxylate phosphabetaines were carried out and studied to enhance the biological activity previously synthesized carboxylate phosphabetaines. As a result these reactions, original structure was destroyed with formation quaternary salts phosphonium triiodide. The composition confirmed by complex physical research methods, including NMR, IR spectroscopy, elemental anal...

Carboxylate reductases (CARs) are valuable catalysts for the selective one-step reduction of carboxylic acids to their corresponding aldehydes. In recent years, numerous new CARs have been made available, studied and applied in context biocatalytic syntheses. The preparation aldehydes as end products flavor fragrance sector integration cascade reactions with key intermediates represent two majo...

4-n- prophyl- 1,2,4- triazoline-3-5- dione was synthesized from n-propylisocyanate and ethylhydrazine carboxylate in several steps. The title compound was isolated as pink crystals in high yield and purity. This compound was fully characterized by IR and H-NMR spectroscopy