Mosquitoes can be found in almost every country. Many mosquito repellents have been introduced to the market order combat them. The mosquitos, on other hand, developed a resistance Not only that, but users are experiencing variety of known and unknown negative side effects. As result, poly herbal insect repellent gel has an attempt give dependable, long-lasting, full protection from bites by de...

Oral delivery of antipsychotic drugs like Ziprasidone HCl has a disadvantage gastric disturbance and lack adherence to the treatment. In present study, loaded ethosomal gel was formulated avoid disadvantages oral delivery. The ethosomes were prepared using Lipoid S 75 with Isopropyl alcohol Propylene glycol as solvents. evaluated for different parameters particle size, poly dispersibility index...

The present investigation was to prepare and evaluate bioadhesive vaginal gel containing clotrimazole loaded microspheres a novel delivery system for vaginal use. Bioadhesive gel was prepared by incorporating drug loaded microspheres using bioadhesive polymer carbopol 934. Microspheres were prepared by spray drying technique using Eudragit RS-100 and RL-100 polymers with different drug/polymer ...

The problem of poor bioavailability and clinical efficacy of curcumin can be sorted out after converting crystalline Curcumin (CrysCur) into amorphous NanoCurcumin (NanoCur). Amorphous NanoCur was prepared by converting into nanoemulsion (o/w) using water titration method. The formulation were pre-screen by different physical stress tests, followed by in vitro release study, zeta potential, vis...

Abstract: Aim and Objectives: The main motto of this work was to search the additive effect Datura stramonium leaves mucilage in making buccoadhesive film by taking Aceclofenac as a model drug. Materials Methods: Nine formulations buccal films were made using Carbopol 934 P varying proportions Ethyl Cellulose D. mucilage. judged for compatibility studies physical constraints including content d...

The carbon nanotubes represent an innovative platform for controlled and targeted drug release in several biomedical applications. Carbon nanotube is one of the most efficient dispersed nano-systems with narrow size distribution ranges from 10-240 nm. possess remarkable electrical, thermal, mechanical conductivity which enables to be functionalized enhance solubility as well biocompatibility po...

Objective: The envisaged research work aims to develop a nanosponge loaded gel for the treatment of Streptococcal gangrene. Methods: In present study, permeability is enhanced by targeted drug release formulation topical clindamycin phosphate nanosponges were prepared emulsion solvent diffusion method using ethyl cellulose as retardant polymer and PVA surfactant or emulsifier. Nanosponges chang...

Carbopol is a polyanionic carbomer used in man for topical application and drug delivery purposes. However parenteral administration of Carbopol in animal models results in systemic adjuvant activity including strong pro-inflammatory type-1 T-cell (Th1) polarization. Here we investigated potential pathways of immune activation by Carbopol by comparison with other well-characterized adjuvants. C...

Objective: The focus of this research was out whether a transfersomal gel formulation for transdermal delivery Metronidazole. Methods: Azole Antifungals include metronidazole, which is used to treat fungal and yeast infections. Transferosomes are supra-molecular aggregates that ultra-flexible have high ability penetrate mammalian skin intact. Drug encapsulation in various formulations containin...

Objective: The purpose of the present study is to develop, statistically optimize and evaluate transfersomal gel formulation Tofacitinib citrate via transdermal route by DOE Approach. Materials Methods: Transferosomes are made up with bilayer forming phospholipids biocompatible surfactants like sodium deoxycholate. also acts as edge activator which stabilizes phospholipid increases deformabilit...