Purpose of Study: In the present study, an attempt was made to design and evaluate buccoadhesive bilayer tablets of granisetron hydrochloride (an anti-emetic drug), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Method: Bilayer buccal tablets containing the drug were prepared by direct compression method using combination of...

Chitosan is currently proposed to be one of the most promising polymers in wound dressing development. Our research focuses on its potential as a vehicle for nano-delivery systems destined for burn therapy. One of the most important features of wound dressing is its bioadhesion to the wounded site. We compared the bioadhesive properties of chitosan with those of Carbopol, a synthetic origin pol...

ETHNOPHARMACOLOGICAL RELEVANCE Carica papaya is traditionally used to treat various skin disorders, including wounds. It is widely used in developing countries as an effective and readily available treatment of various wounds, particularly burns. THE AIM OF THE STUDY This study was aimed at investigating the healing efficiency of papaya latex formulated as 1.0 and 2.5% hydrogels. MATERIALS ...

The purpose of the study was to screen the effects of formulation factors on the in vitro release profile of diclofenac sodium from matrix pellets compressed into multiple unit pellet system (MUPS) tablets using design of experiment (DOE). Extended release of diclofenac sodium was accomplished using Carbopol 71G as matrix substance. According to Fractional Factorial Design FFD 2(3-1) four formu...

A gel can be described as the cross-linked material that retains a large amount of solvent inside its medium and if the solvent retained is water, such material is known as hydrogel. Drug therapy of the inflammation of skin is mainly topical. This necessitates the treatment of symptoms, since in most cases causal treatment is impossible due to unknown etiology. Topical corticosteroids are the m...

Tenoxicam is a nonsteroidal antiinflammatory drug, used in the treatment of inflammatory and degenerative disorders of the musculoskeletal system. It is from the oxicam group of nonsteroidal antiinflammatory agents. It is widely prescribed for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout, extraarticular disorders, bursitis, tendonitis, and nonarticular rhe...

Purpose: To prepare and evaluate metformin microspheres for prolonged release. Methods: Metformin microspheres were prepared by non-aqueous solvent evaporation method using various polymers, including ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC), carbopol 934P (CA) and chitosan (CH). The effect of process variables, viz, drug/polymer ratio, stirring rate and type of polymer on the ...

Purpose: To formulate and prepare controlled release (CR) matrix tablets of tramadol HCl using Carbopol 974P and 934 polymers as rate-controlling agents. Methods: The tablets were prepared by direct compression method using various drug to polymer (D:P) ratios. Co-excipients, including carboxymethylcellulose, starch and/or hydroxypropyl methylcellulose were also used to modulate the formulation...

Background: Dry skin conditions’ primary and secondary infections can be treated by using mupirocin topically. By overcoming the disadvantages of ointments, creams, lotions, goal formulation emulgel was to improve occlusive properties gels topical delivery hydrophobic drugs with favorable for dry conditions, as well investigate impact concentration different gelling agents (carbopol 940, carbop...