نتایج جستجو برای: carbohydrate sulfotransferase 6 gene chst6

تعداد نتایج: 2014793  

Journal: : 2023

The review presents modern studies the effect of genetic polymorphisms on efficienty and safety therapy with new oral anticoagulants. Hepatic carboxylesterase encoded by CES1 gene P-glycoprotein ABCB1 affect dabigatran pharmacokinetics. role glucuronidation enzymes (UGT2B15, UGT1A9, UGT2B7) involved in active metabolism is poorly understood. An increase peak apixaban concentration was noted pat...

2017
Yoshiro Kai Koichi Tomoda Hiroyuki Yoneyama Masahiro Kitabatake Atsuhiro Nakamura Toshihiro Ito Masanori Yoshikawa Hiroshi Kimura

Pulmonary fibrosis is a progressive lung disorder characterized by interstitial fibrosis, for which no effective treatments are available. Chondroitin sulfate proteoglycan (CSPG) has been shown to be a mediator, but the specific component of glycosaminoglycan chains of CSPG has not been explored. We show that chondroitin sulfate E-type (CS-E) is involved in fibrogenesis. Small interfering RNA (...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Hiroki Utsunomiya Kiyoshi Ito Takashi Suzuki Takako Kitamura Chika Kaneko Taisuke Nakata Hitoshi Niikura Kunihiro Okamura Nobuo Yaegashi Hironobu Sasano

PURPOSE Intratumoral metabolism and synthesis of estrogens are considered to play important roles in the pathogenesis and/or development of human endometrial carcinoma. Steroid sulfatase hydrolyzes biologically inactive estrogen sulfates to active estrogens, whereas estrogen sulfotransferase sulfonates estrogens to estrogen sulfates. However, the status of steroid sulfatase and/or estrogen sulf...

Journal: :Drug Metabolism and Pharmacokinetics 1998

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