Chimeric-antigen-receptor (CAR) T cells targeting CD19 show dramatic remissions in refractory or relapsed acute lymphoblastic leukemia. Interleukin-6 (IL-6) has been associated with severe cytokine release syndrome (CRS) following CAR T cell treatment, leading to significant toxicity and death. CRS could be treated with an antiIL6-receptor antibody, with reversal of most of the inflammatory res...

Chimeric antigen receptor (CAR) T cells can produce durable remissions in hematologic malignancies that are not responsive to standard therapies. Yet the use of CAR T cells is limited by potentially severe toxicities. Early case reports of unexpected organ damage and deaths following CAR T-cell therapy first highlighted the possible dangers of this new treatment. CAR T cells can potentially dam...

1 In natural traffic flow, the information from preceding vehicles determines driver behavior predominantly. 2 With the availability of connected vehicle technologies (CVT), drivers can receive information from both 3 preceding and following vehicles. This creates new opportunities for vehicle coordination and control at 4 the microscopic level based on bi-directional information. Although the ...

The car following model is a key element in driver behavior modeling. A PD controller car-following model is a popular and realistic model. A big problem met in designing driver behavior models is the absence of reliable data from the real traffic. However, experiments using an instrumented vehicle driven in the real world supplied the radar tracking data. This paper first analyzes the desired ...

Heavy vehicles are significantly longer and heavier than passenger cars and consequently have quite different acceleration and braking capabilities. Heavy vehicle manoeuvres are therefore likely to influence drivers’ vehicle-following behaviour differently to cars. Heavy vehicles can also influence the behaviour of drivers of other vehicles while following a heavy vehicle. This paper used data ...