PURPOSE After intraocular lens (IOL) implant surgery for cataract, cell growth on the posterior capsule is responsible for renewed visual impairment in approximately 30% of patients. The authors have, therefore, developed a human lens capsule system to study this growth in vitro. METHODS Sham cataract surgery, including anterior capsulorhexis, nucleus hydroexpression, and aspiration of lens f...

Cryptococcus neoformans is a facultative intracellular pathogen. The most distinctive feature of C. neoformans is a polysaccharide capsule that enlarges depending on environmental stimuli. The mechanism by which C. neoformans avoids killing during phagocytosis is unknown. We hypothesized that capsule growth conferred resistance to microbicidal molecules produced by the host during infection, pa...

By stimulation of serial points of the caudate nucleus and internal capsule in cat with multilead electrode, pericruciate responses are elicited easily by internal capsule stimulation but responses by caudate nucleus stimulation are due to the current spread to the interpal ca psule. A part of the diffuse thalamic projection system has been inferred to pass through the internal capsule. It was ...

The capsular swelling or quellung reaction was reported almost 100 years ago and described the effect of Abs on the appearance of microbial capsules. Despite widespread use to assess Ab binding to capsules, relatively little is known as to the mechanism of this effect or its biological consequences. The fungus Cryptococcus neoformans is an attractive system to study capsule reactions because it...