Serum leucine-aminopeptidase (LAP) and cystine-aminopeptidase (CAP) determinations have been made using a chemical method based on enzymatic hydrolysis of l-leucine-/?-naphthylamide-hydrochloride and cystine-di-/?naphthylamide, respectively. Fractionation of serum proteins by gel filtration on "Sephadex-G 200" has been used for separation of LAP and CAP (oxytocinase). — CAP which appears during...

The Klebsiella aerogenes hutUH operon is preceded by a promoter region, hut(P), that contains two divergent promoters (hutUp and Pc) which overlap and are alternately expressed. In the absence of the catabolite gene activator protein-cyclic AMP (CAP-cAMP) complex, Pc is predominantly expressed while hutUp is largely repressed. CAP-cAMP has the dual effect of repressing transcription from Pc whi...

BACKGROUND Community-acquired pneumonia (CAP) is frequently associated with the very young and the elderly but is a largely underrecognized burden among working-age adults. Although the burden of CAP among the elderly has been established, there are limited data on the economic burden of CAP in the employed population. OBJECTIVE To assess the economic impact of CAP in US working-age adults fr...

BACKGROUND The role of mixed pneumonia (virus+bacteria) in community-acquired pneumonia (CAP) has been described in recent years. However, it is not known whether the systemic inflammatory profile is different compared to monomicrobial CAP. We wanted to investigate this profile of mixed viral-bacterial infection and to compare it to monomicrobial bacterial or viral CAP. METHODS We measured ba...

Prevention of implant-associated infections has been one of the main challenges in orthopaedic surgery. This challenge is further complicated by the concern over the development of antibiotic resistance as a result of using traditional antibiotics for infection prophylaxis. The objective of this study was to develop a technique that enables the loading and local delivery of a unique group of ca...

Previously we reported that calcium phosphate nanoparticles (CAP) represented a superior alternative to alum adjuvants in mice immunized with viral protein. Additionally, we showed that CAP was safe and elicited no detectable immunoglobulin E (IgE) response. In this study, we demonstrated that following mucosal delivery of herpes simplex virus type 2 (HSV-2) antigen with CAP, CAP adjuvant enhan...

BACKGROUND We hypothesized that obstructive sleep apnea (OSA) can predispose individuals to lower airway infections and community-acquired pneumonia (CAP) due to upper airway microaspiration. This study evaluated the association between OSA and CAP. METHODS We performed a case-control study that included 82 patients with CAP and 41 patients with other infections (control group). The controls ...

Growing microtubules are protected from depolymerization by the presence of a GTP or GDP/Pi cap. End-binding proteins of the EB1 family bind to the stabilizing cap, allowing monitoring of its size in real time. The cap size has been shown to correlate with instantaneous microtubule stability. Here we have quantitatively characterized the properties of cap size fluctuations during steady-state g...

Because most sediment contaminants are highly sorptive, their migration through a cap is retarded due to transient accumulation on the clean cap material. Thus the time for typical sediment contaminants to migrate through a cap can be hundreds or thousands of years if the cap is designed and maintained to retain its integrity throughout that period. Effective design of a cap to isolate contamin...

Many say the market for the shares of smaller companies—so called small-cap and mid-cap stocks—offers greater opportunity for active management to add value than does the large-cap market. The underlying notion is that the market for small and medium caps is less efficient than the large-cap market, and, therefore, security mispricing is more prevalent there. It is true that fewer securities an...