background bone marrow and adipose tissue are two main sources of mesenchymal stem cells (mscs). some of studies suggest that there are some differences in gene expression profile of mscs-derived from various tissues. to investigate gene expression profile by qrt-pcr, an appropriate reference gene with stable expression level should be chosen for normalizing data.  this study was designed to ev...

Objective- To investigate the effect of intratendinous injection of bMSCs on the rate and extent of tendon healing after primary repair in a rabbit model. Design- Experimental study. Animals- Twenty seven skeletally mature New Zealand white rabbits weighing 1.8- 2.5 kg were used. Twenty rabbits were used as the experimental animals, and seven others were used as a source of bone marrow-derived ...

dental tissues provide an alternate source of stem cells compared with bone marrow and have a similar potency as that of bone marrow derived mesenchymal stem cells. it has been established there are six types of dental stem cells: dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, periodontal ligament stem cells, dental follicle progenitor ...

Background: Acute myeloid leukemia (AML) is characterized by the proliferation of myeloid precursors and abnormal differentiation of hematopoietic stem cells, which results in the accumulation of immature cells in the bone marrow (BM). The accumulation of these cells in the bone marrow causes molecular and cellular changes in the microenvironment of the bone marrow. The adiponectin hormone orig...

Stem cells are emerging as an attractive option because of their intrinsic ability vectors for drug delivery to diseased tissues. The term stem or was first introduced by a Russian histologist, Alexander Maksimov (1874-1928). purpose this study is describe the research and development cell applications stroke. This literature (review article) regarding (stem cells) in stroke which has been disc...

Currently several studies are being carried out on various properties of mesenchymal stem cells (MSCs)however there are a few investigations about drug metabolizing properties of these cells. The aim of thisstudy was to measure the key factors involved in drug metabolism in human bone marrow MSCs. For thispurpose, cellular glutathione (GSH), glutathione Stransferase (GSTs) and...

We have previously shown that grafts with low doses of bone marrow ( 4 x 108 cells/kg) after 1200 R total-body irradiation (TBI) are successful in DLA-identical, but not DIA-nonidentical littermate or unrelated dogs, suggesting a locus of resistance associated with the major canine histocompatibility complex (DIA). Addition of viable donor blood leukocytes to the marrow inoculum has consistentl...

introduction demyelination is a common lesion of spinal cord injury; cell therapy is an approach for replacing the lost oligodendrocytes. objective in this study, bone marrow stromal cells (bmscs) have been transdifferentiated into oligodendrocyte-like cells (olcs) and used in cytotherapy of contused spinal cords in rats. materials and methods the bmscs were collected from rat long bones, cultu...