background: activation of the ubiquitin-proteasome pathway in various malignancies, including colorectal cancer, is established. this pathway mediates the degradation of damaged proteins and regulates growth and stress response. the novel human gene, ube2q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies. we sought to investigate the ...

the mitochondrial dna (mtdna) mutations in mitochondrial coding and non coding regions seem to be important in carcinogenesis. the aim of this investigation was to evaluate coding region (mt-trnaphe and trnapro) and non-coding sequence, mitochondrial displacement loop (mtdna d-loop), in the cancerous and non-cancerous lesions of iranian patients with breast cancer (bc). genomic dna was extracte...

Pancreatic cancer (PC) is characterized by rapid tumor spread, and very few patients with PC survive for more than 5 years. It is imperative to discover additional diagnostic biomarkers or specific therapeutic targets in order to improve the treatment of patients with PC. In search for useful biomarkers, we analyzed ten pairs of non-cancerous and ...

Background. Response gene to complement 32 (RGC32), induced by activation of complements, has been characterized as a cell cycle regulator; however, its role in carcinogenesis is still controversial. In the present study we compared RGC32 promoter methylation patterns and mRNA expression in breast cancerous tissues and adjacent normal tissues. Materials and Methods. Sixty-three breast cancer ti...

PURPOSE Human kallikrein gene 6 (KLK6) is a member of the human kallikrein gene family, and recent studies have found that many kallikreins have altered expression patterns in various malignancies. The purpose of the current study was to quantify the expression of KLK6 in malignant and benign colorectal tissues and to statistically analyze whether KLK6 expression levels correlate with clinicopa...

Fatty acid binding proteins (FABPs) are intracellular lipid-binding proteins that are involved in a variety of biological cellular processes, including tumorigenesis. In this study, we explored the expression pattern of FABP3 and FABP4 in non-small cell lung cancer (NSCLC) as well as their roles in prognosis. We determined mRNA expression of FABP3 and FABP4 in matched pairs of cancerous and non...

BACKGROUND Caveolin-1 has been shown to be down-regulated in human colon cancer and involved in colon tumorigenesis. We investigated the mechanism. MATERIALS AND METHODS Cancerous and nearby non-cancerous tissues of 185 sporadic colorectal cancer samples were enrolled in this study. Methylation-specific PCR was performed to explore the mechanism of regulation of caveolin-1 gene expression. ...

NKp44 and NKp30 splice variant profiles have been shown to promote diverse cellular functions. Moreover, microenvironment factors such as TGF-β, IL-15 and IL-18 are able to influence both NKp44 and NKp30 splice variant profiles, leading to cytokine-associated profiles. Placenta and cancerous tissues have many similarities; both are immunologically privileged sites and both share immune toleranc...

background: early detection is a key to survival for gastric cancer. molecular markers such as mirna (microrna) can have great importance in the early diagnosis of gastric cancer. expression of mir-21 and mir-221 are deregulated in many types of human cancers. this study aimed to investigate the differences in mirna expression patterns within the iranian population. methods: total rna was extra...