نتایج جستجو برای: cancer risk cr
تعداد نتایج: 1780961 فیلتر نتایج به سال:
Complete response (CR) rates reported for cytotoxic chemotherapy for late-stage cancer patients are generally low, with few exceptions, regardless of the solid cancer type or drug regimen. We investigated CR rates reported in the literature for clinical trials using chemotherapy alone, across a wide range of tumour types and chemotherapeutic regimens, to determine an overall CR rate for late-st...
PURPOSE Patients with Lynch syndrome are at high risk for colon and endometrial cancer, but also at an elevated risk for other less common cancers. The purpose of this retrospective cohort study was to provide risk estimates for these less common cancers in proven carriers of pathogenic mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6. PATIENTS AND METHODS Data were pooled fr...
Hexavalent chromium [Cr(VI)] is a known etiological factor in human lung cancer. Cr(VI) exposure-related lung cancer has a high mutation incidence in the p53 gene. Upon intake in human cells Cr(VI) is reduced to Cr(III), which is able to conjugate with amino acids and consequently form either binary Cr(III)-DNA or ternary Cr(III)-amino acid-DNA adducts. Both binary and ternary Cr(III)-DNA adduc...
BACKGROUND Patterns of therapy switching in patients receiving long-acting opioids have not been well documented. OBJECTIVE To compare therapy switching among patients beginning treatment with controlled-release (CR) oxycodone, transdermal fentanyl, or CR morphine sulfate. METHODS Using a US healthcare claims database, we identified patients beginning treatment with CR oxycodone, transderma...
gene-by-environment interaction studies: revelations and remedies. Epidemiology 2011;22:400–07. 4 Weinberg CR, Shi M, Umbach DM. A sibling-augmented case-only design for assessing multiplicative gene-environment interaction. Am J Epidemiol 2011;174:1183–89. 5 Kistner EO, Shi M, Weinberg CR. Using cases and parents to study multiplicative gene-by-environment interaction. Am J Epidemiol 2009;170:...
BACKGROUND Based principally on findings in three studies, the collaborative reanalysis (CR), the Women's Health Initiative (WHI) and the Million Women Study (MWS), it is claimed that hormone replacement therapy (HRT) with estrogen plus progestogen (E+P) is now an established cause of breast cancer; the CR and MWS investigators claim that unopposed estrogen therapy (ET) also increases the risk,...
Aim: Active mining in Kilembe copper mine, Kasese district, Uganda ended about four decades ago. However, various health problems are believed to be from the effect of activities that took place area. In this study therefore, we quantified concentration trace metals: chromium (Cr), cadmium (Cd), zinc (Zn), iron (Fe), lead (Pb), arsenic (As) and (Cu) cabbages tomatoes grown area assessed risks c...
Chromium exists in many different oxidation states in the environment, Cr(VI) and Cr(III) being the most stable forms. Chromium has been known for over 100 years to be a human carcinogen. The greatest risk of cancer from chromium exposure is associated with Cr(VI). Cr(VI) enters cells via the sulfate anion transporter system and is reduced to intermediate oxidation states, such as Cr(V) and Cr(...
Risk of pancreatic cancer, the fourth deadliest cancer in the United States, is increased by obesity. Calorie restriction (CR) prevents obesity, suppresses carcinogenesis in many models, and reduces serum levels of IGF-1. In the present study, we examined the impact of CR on a model of inflammation-associated pancreatitis and pancreatic dysplasia, with a focus on the mechanistic contribution of...
Soil properties may change due to climate change, but in recent times, the changes occur as a result of anthropogenic activities such metal workshop operations. This study was conducted assess impact contamination on human health operating workshops. In this research work which carried out estimated risk heavy around workshops, five different Garejin Oga Abdul (GOA), Nakowa Welding Construction...
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