BACKGROUND Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects, such as fluid flow and fluid shear stress (FSS), which may enable bone cells to detect external mechanical signals. Interstitial bone fluid flow is known to occur in lacunar-canalicular porosity (PLC). METHODS In order to characterize lacunar-canalicular fluid flow behavior, a hierarch...

The cases of sixty patients in whom a burst fracture of a thoracic or lumbar vertebral body had been treated with posterior instrumentation and arthrodesis less than two weeks after the injury were retrospectively reviewed. Thirty of the patients had an associated laminar fracture. Eleven of the thirty, all of whom had a lumbar fracture and a preoperative neurological deficit, were noted at ope...

Tendons function to transmit loads from muscle to move and stabilize joints and absorb impacts. Functionality of lacerated tendons is diminished, however clinical practice often considers surgical repair only after 50% or more of the tendon is lacerated, the "50% rule." Few studies provide mechanical insight into the 50% rule. In this study cyclic and static stress relaxation tests were perform...

Osteocytes are the most frequent bone cells connected with each other through cell processes within tiny tubular-shaped canaliculi. The so-called osteocyte lacunar-canalicular network (LCN) plays a crucial role in remodeling and mineral homeostasis. Given critical nature of these functions, it is herein hypothesized that LCN must be structurally “overengineered” to provide resilience. This hypo...

IMAGES However, 48 hours after the operation, she had dyspnea along with subcutaneous emphysema on her shoulder (Fig. 1). Diagnostic bronchoscopy revealed an approximately 1.5-cm-sized vertical tracheal laceration above the carina with split thickness (Fig. 2). She was started on antibiotics, O2 inhalation, expectorants and non-per oral. The emphysema spontaneously resolved. The patient was dis...

There was a partial thickness laceration of the right cornea at the junction of the middle and lower thirds extending in an irregular horizontal line from side to side. From the depth of this laceration the cornea was split to the lower limbus and in the lamellar pocket so formed were embedded multiple fragments of a shattered corneal contact lens. At no point did this lamellar laceration penet...

Glutathione (GSH) plays a critical role in many cellular processes, including the metabolism and detoxification of oxidants, metals, and other reactive electrophilic compounds of both endogenous and exogenous origin. Because the liver is a major site of GSH and glutathione S-conjugate biosynthesis and export, significant effort has been devoted to characterizing liver cell sinusoidal and canali...

Isolated rat hepatocyte couplets were used to perform the comparative study of two widely used immunosuppressors, cyclosporin A (CsA) and tacrolimus (FK506) on hepatocanalicular function. We assessed canalicular function by counting the percentage of couplets that were able to accumulate the fluorescent cholephile, cholyl-lysyl-fluorescein (CLF), into the canalicular vacuole between the two cel...

Fibrates are commonly used lipid-lowering agents that act via PPARalpha, a member of the nuclear hormone receptor superfamily. The mechanism(s) of fibrate-induced changes in the hepatic canalicular membrane and bile lipids are still unknown. Therefore, the aim of this study was to investigate the influence of fibrates on hepatic lipid metabolism and to assess the hepatocellular cytoprotective e...

Themes of Self-Laceration Towards a Modicum of Control in Nineteenth Century Russia as Expressed by Dostoevsky in The Brothers Karamazov The majority of the academic discourse surrounding Dostoevsky and his epic, The Brothers Karamazov, has been directed toward the philosophic and religious implications of his characters. Largely overlooked, however, is the theme of laceration. In the greater s...