نتایج جستجو برای: calm wt

تعداد نتایج: 140699  

Journal: :Heart Rhythm 2023

Calmodulin (CaM)-mediated long QT syndrome (CaM-LQTS) and CaM-mediated catecholaminergic polymorphic ventricular tachycardia (CaM-CPVT) are genetic arrhythmia disorders (calmodulinopathies) characterized by a high prevalence of life-threatening arrhythmias occurring very early in life. Three distinct genes (CALM1, CALM2, CALM3) encode for the identical CaM protein. Conventional pharmacotherapie...

2012

This summary is the first in a series of five short documents based on a literature review published in 2011. In what follows, we first present the mechanisms of action underlying traffic-calming strategies, as these mechanisms help to explain and predict the effects of calming interventions on the number and severity of collisions. Next, we summarize the results of studies having evaluated two...

2010
Roman M. Wittig Christophe Boesch

The adaptive function of bystander initiated post-conflict affiliation (also: consolation & appeasement) has been debated for 30 years. Three influential hypotheses compete for the most likely explanation but have not previously been tested with a single data set. The consolation hypothesis argues that bystander affiliation calms the victim and reduces their stress levels. The self-protection h...

2009
R. van Woesik

Most corals in tropical localities broadcast their gametes into the water column, yet we have a poor understanding of what forces reproductive schedules. Moreover, recent studies show considerable geographical variation in the duration of the coral spawning season. For example, on the Great Barrier Reef, corals display tight coupling, while corals in Kenya spawn over seven months. This study re...

Journal: :Continental shelf research 2007
David K Ralston Mark T Stacey

Field observations of flow and sediment transport in a tributary channel through intertidal mudflats indicate that suspended sediment was closely linked to advection and dispersion of a tidal salinity front. During calm weather when tidal forcing was dominant, high concentrations of suspended sediment advected up the mudflat channel in the narrow region between salty water from San Francisco Ba...

2007
Richard M. Adler

Guiding organizations through transformational changes such as restructuring or adopting new technologies is a daunting task. Such changes generate workforce uncertainty, fear, and resistance, reducing morale, focus and performance. Conventional project management techniques fail to mitigate these disruptive effects, because social and individual changes are non-mechanistic, organic phenomena. ...

2016
Klaartje Somers Daria A. Chudakova Shiloh M.C. Middlemiss Victoria W. Wen Molly Clifton Alan Kwek Bing Liu Chelsea Mayoh Angelika Bongers Mawar Karsa Sukey Pan Sarah Cruikshank Marissa Scandlyn Wendi Hoang Toshihiko Imamura Ursula R. Kees Andrei V. Gudkov Olga B. Chernova Michelle Haber Murray D. Norris Michelle J. Henderson

There is an urgent need for the development of less toxic, more selective and targeted therapies for infants with leukemia characterized by translocation of the mixed lineage leukemia (MLL) gene. In this study, we performed a cell-based small molecule library screen on an infant MLL-rearranged (MLL-r) cell line, PER-485, in order to identify selective inhibitors for MLL-r leukemia. After screen...

2014
John N A Brown Martin Hitz Gerhard Leitner

John N A Brown Interactive Systems (ISYS), Alpen-Adria-Universität (AAU) Universitätsstraße 65-67 9020 Klagenfurt, Carinthia, Austria, and Centre Tecnològic de Recerca per a la Dependència i la Vida Autònoma (CETpD), Universitat Politècnica de Catalunya (UPC) Rambla de l’Exposició, 59-69 08800 Vilanova i la Geltrú, Catalonia, Spain [email protected] Martin Hitz ISYS, AAU Universitätsstraße 65...

Journal: :Proceedings. Biological sciences 2010
R van Woesik

Most corals in tropical localities broadcast their gametes into the water column, yet we have a poor understanding of what forces reproductive schedules. Moreover, recent studies show considerable geographical variation in the duration of the coral spawning season. For example, on the Great Barrier Reef, corals display tight coupling, while corals in Kenya spawn over seven months. This study re...

Journal: :Lab on a chip 2017
Ning Shao Jianwei Chen Jiaying Hu Rong Li Dabing Zhang Shujuan Guo Junhou Hui Peng Liu Litao Yang Sheng-Ce Tao

There is an urgent need for rapid, low-cost multiplex methodologies for the monitoring of genetically modified organisms (GMOs). Here, we report a C[combining low line]apillary A[combining low line]rray-based L[combining low line]oop-mediated isothermal amplification for M[combining low line]ultiplex visual detection of nucleic acids (CALM) platform for the simple and rapid monitoring of GMOs. ...

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