PURPOSE This study aimed to explore the role of the Twist gene in the epithelial-mesenchymal transition of ovarian cancer. METHODS An RNA interference plasmid expressing a small interfering RNA (siRNA)-targeting Twist (Twist siRNA vector) was designed, constructed, and transfected into the human ovarian cancer cell line A2780. Transfection efficiency was assessed under a fluorescence microsco...

Twist, a key regulator of epithelial-mesenchymal transition (EMT), plays an important role in the development of a tumorigenic phenotype. Energy metabolism reprogramming (EMR), a newly discovered hallmark of cancer cells, potentiates cancer cell proliferation, survival, and invasion. Currently little is known about the effects of Twist on tumor EMR. In this study, we found that glucose consumpt...

INTRODUCTION Today, development of materials technology using biomass is expected for creation of a sustainable society. Especially, the composite consisting of plant-based natural fibers and biodegradable resin, so-called the fully-green composites, is much expected for practical use. So far, we made textile green composites using biodegradable resin and plain woven ramie fabric and explored t...

We use monoidal category methods to study the noncommutative geometry of nonassociative algebras obtained by a Drinfeld-type cochain twist. These are the so-called quasialgebras and include the octonions as braided-commutative but nonassociative coordinate rings, as well as quasialgebra versions Cq(G) of the standard q-deformation quantum groups. We introduce the notion of ribbon algebras in th...

A bstract We construct AdS 4 × Σ and 2 $$ {\Sigma}_{\mathfrak{g}} Σ g solutions in F(4) gauged supergravity six dimensions, where is a two dimensional manifold of non-constant curvature with conical singularities at its poles, called spindle, constant Riemann surface ge...

The transcription factor TWIST is an important factor in regulating epithelial-mesenchymal transition (EMT) and tumor metastasis. To explore the functions of TWIST in hypopharyngeal cancer, we investigated if overexpression of TWIST has an effect on FaDu cell morphology, and if alteration of TWIST has an effect on E-cadherin, N-cadherin, c-fos, MM...

The effect of D-cycloserine on the establishment of twist states in Bacillus subtilis macrofibers was examined. Macrofibers produced in the presence of the drug differed in twist compared with those produced in its absence. The degree of twist alteration was dependent on the concentration of D-cycloserine in the growth medium. Macrofibers of different twist states representative of the entire t...

Basic helix-loop-helix (bHLH) transcription factors are known as key regulators for mesenchymal differentiation. The present study showed that overexpression of Twist-1, a bHLH transcription factor, suppresses bone morphogenetic protein (BMP)-induced osteoblast differentiation, and downregulation of endogenous Twist-1 enhances BMP signaling. Maximal inhibition of BMP signaling was observed when...