The effects of phenylarsine oxide, a phosphotyrosine phosphatase inhibitor, on early signal transduction events in human T cells were studied. Simultaneous stimulation of T cells with anti-CD3 monoclonal antibody and phenylarsine oxide prevented increased tyrosine phosphorylation of phospholipase C gamma 1. In contrast, treatment of resting T cells with phenylarsine oxide alone resulted in incr...

This study examined the effect of 25% deuterium oxide in drinking water on systolic blood pressure, uptakes of calcium, and rubidium 86 by aortas of Dahl salt-sensitive rats on 0.4% (low) and 8% (high) sodium chloride (salt) diet. Twenty-four rats were divided into four groups. Groups I and II were on the low salt diet and groups III and IV on the high salt diet from 6 weeks of age. Additionall...

The regulation of renin release is unusual in that intracellular calcium reportedly acts as an inhibitory second messenger. Increased calcium not only inhibits renin release but is a cofactor in nitric oxide synthesis. Also, nitric oxide can inhibit renin release. This study was done in vitro using rat renal cortical slices to determine whether calcium-mediated renin inhibition could be in part...

Dermal drug delivery is highly preferred by patients due to its several advantages. Protein therapeutics have attracted huge attention recently. Since dermal delivery of proteins encounter problems, in this investigation, zinc oxide nanoparticles and calcium phosphate nanoparticles were compared as enhancers for dermal permeation of albumin. Albumin was applied simultaneously with zinc oxide na...

Self-assembled solution micelles prepared from polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) and polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP), have been employed as templates to synthesize copper nanocatalysts which are regarded as an excellent catalyst system for 1D nanomaterial synthesis. We have demonstrated that uniform-sized nanoparticles with diameters ranging from 1 to 15 nm have be...

A thermosensitive nanocatalyst was prepared in the reaction of water-soluble iron(III) porphyrins and thermosensitive polymeric nanospheres with a core-shell structure; its catalytic activity in cyclohexene oxidation by iodosylbenzene was dependent markedly on reaction temperatures in aqueous solution.