OBJECTİVE: In this study, it was aimed to evaluate the antineoplastic efficacy of Teranecron, which is frequently used in veterinary medicine, on human colorectal adenocarcinoma.
 MATERİALS AND METHODS: Teranecron (TRN) its effectiveness and drug Doxorubicin as a positive control. The cytotoxic activity cell line CaCo-2 investigated. MTT proliferation test determine viability rates. ANOVA ...

Histamine intolerance occurs when there is an imbalance between histamine production and the capacity for degradation. Diamine oxidase (DAO) main enzyme catabolism of ingested degradation in gastrointestinal tract its deficiency has been linked to allergy-like symptoms. Psychostimulant drugs are commonly used treat Attention Deficit Hyperactivity Disorder (ADHD), but their interaction with DAO ...

There is still relatively limited information about mechanisms of gene expression in enterocytes and mechanisms by which gene expression is regulated during enterocyte differentiation. Using the human intestinal epithelial cell line Caco-2, which spontaneously differentiates from a cryptlike to a villouslike enterocyte, we have previously shown that there is a marked increase in transcription o...

OBJECTIVE To investigate the effects of resveratrol and tannic acid on apoptosis, and Bcl-2 homologous antagonist/killer (Bak) and fas associated death domain (FADD) proteins in the CaCo-2 cell line. METHODS In the present study, resveratrol and tannic acid were administrated in the CaCo-2 cell line at doses of 25, 50, and 100 microM. The CaCo-2 cells were grown and cultured in the Medical Bi...

BACKGROUND Brachyspira pilosicoli is an anaerobic spirochete that has received relatively little study, partly due to its specialized culture requirements and slow growth. This bacterium colonizes the large intestine of various species, including humans; typically, a dense layer of spirochete cells may be found intimately attached by one cell end to the surface of colonic enterocytes. Colonized...

Nanotechnology has gained great interest due to its widespread application. Anticancer activity of Origanum majorana extract and silver nanoparticles was investigated by MTT assay using human pancreatic adenocarcinoma cell lines (Capan-1), mouse normal fibroblast (L929), colon line (Caco-2). AgNPs@Om exhibited the excellent cytotoxic effect on Capan-1 with viability 29.17% 25.70%, 22.49%, 21.16...

Curcumin has been traditionally used in food recipes for biological health benefits. However, these properties are compromised due to its very low bioavailability. Thus, this work assessed the impact of using natural potential bioenhancers improve intestinal permeability and understanding interaction flavonoids with curcuminoids through molecular dynamic simulation. The (Papp) was measured on h...