We recently established a two-stage in vitro assay for KSR kinase activity in which KSR never comes in contact with any recombinant kinase other than c-Raf-1 and defined the epidermal growth factor (EGF) as a potent activator of KSR kinase activity (Xing, H. R., Lozano, J., and Kolesnick, R. (2000) J. Biol. Chem. 275, 17276-17280). That study, however, did not address the mechanism of c-Raf-1 s...

Excitotoxicity results in a significant increase in Ca2+ influx; essentially from open N-Methyl-D-aspartate receptors (NMDARs) channels that cause a secondary rise in the intracellular Ca2+ concentration. It is correlated with neuronal death induced by Ca2+ overload. Dysfunction of NMDARs is associated with excitotoxic neuronal death in neurodegenerative disorders. In this study, the effects of...

objective(s):this study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on pyramidal neurons of hippocampus in 18 and 32 day mice offspring. materials and methods: thirty female mice were randomly allocated into cases and controls. in case group, animals received morphinesulfate 10 mg/kg.body weight intraperitoneally during 7 days bef...

We studied the effect of pH on ligand binding in wild-type lactose permease or mutants in the four residues-Glu-269, Arg-302, His-322, and Glu-325-that are the key participants in H(+) translocation and coupling between sugar and H(+) translocation. Although wild-type permease or mutants in Glu-325 and Arg-302 exhibit marked decreases in affinity at alkaline pH, mutants in either His-322 or Glu...

8.1.1 Variation in Phenotypic Traits ................................. 264 8.1.2 Familial Resemblance and Heritability ................... 264 8.1.3 The Special Case of Twins ...................................... 267 8.1.4 Embedding a Single Measured Gene Infl uencing a Continuous Trait ................................ 269 8.1.5 A Model for Variance Partitioning .......................... 269 ...

II1. Regu la t ion of t r anspor t ac t iv i ty by amino acid avai lab i l i ty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269 A, Regula t ion of System A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269 B. Regula t ion of System L . . . . . . . . . . . . . . ....

Antigen stimulation of cultured bone-marrow-derived mast cells sensitized with specific monoclonal IgE induced cell degranulation and paf-acether (paf; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) biosynthesis via the deacylation/acetylation (remodelling) pathway. Phorbol myristate acetate (PMA; 20-100 ng/ml) triggered only acetyltransferase activation, without concomitant lyso-paf (1-O-alky...

In this research paper, chemically activated Thuja Occidentalis leaves carbon (CATLC) is used as an adsorbent for the removal of calcium (Ca2+) ion from aqueous solution. CATLC is prepared and characterized by FTIR, SEM and EDX. The impact of pH, adsorbent dosage, contact period and initial concentration of Ca2+ on the adsorption performance of CATLC for Ca2+ removal are examined by batch studi...

AMA Maksym J, Kapłon-Cieślicka A, Scisło P, et al. Safety and efficacy of percutaneous atrial appendage closure followed by antiplatelet therapy in a high-risk population: single-center experience with WATCHMAN device. Advances Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2023;19(3):262-269. doi:10.5114/aic.2023.131480. APA Maksym, J., Kapłon-Cieślicka, A., Scisło, P., Huczek...